Granulocytes

Granulocytes are cells of the innate immune system that are characterized by granules in their cytoplasm. The three main types of granulocytes are neutrophils, eosinophils and basophils.

Latest Research and Reviews

  • Reviews |

    Neutrophils accumulate in the circulation of patients with cancer, and the neutrophil-to-lymphocyte ratio is a widely used biomarker. However, the effects of neutrophils on tumour development and progression, and the efficacy of therapies, remain relatively unknown. In this Review, the authors draw on data from animal models and patients with cancer to provide an overview of the effects of neutrophils in cancer.

    • Merav E. Shaul
    •  & Zvi G. Fridlender
  • Research | | open

    Antiphospholipid syndrome is characterised by increased neutrophil extracellular trap formation (NETosis) and, consequently, increased thrombotic events. Here Ali et al. show that treatment with adenosine receptor agonists suppresses NETosis and venous thrombosis in mouse models of antiphospholipid syndrome.

    • Ramadan A. Ali
    • , Alex A. Gandhi
    • , He Meng
    • , Srilakshmi Yalavarthi
    • , Andrew P. Vreede
    • , Shanea K. Estes
    • , Olivia R. Palmer
    • , Paula L. Bockenstedt
    • , David J. Pinsky
    • , Joan M. Greve
    • , Jose A. Diaz
    • , Yogendra Kanthi
    •  & Jason S. Knight
  • Research | | open

    Influenza viremia is rare in human blood and not well studied. Here, the authors show that influenza can be found in human platelets and that platelet engulfment of influenza A results in TLR7-dependent C3 release, which in turn promotes neutrophil-DNA release and formation of platelet-DNA aggregates.

    • Milka Koupenova
    • , Heather A. Corkrey
    • , Olga Vitseva
    • , Giorgia Manni
    • , Catherine J. Pang
    • , Lauren Clancy
    • , Chen Yao
    • , Jeffrey Rade
    • , Daniel Levy
    • , Jennifer P. Wang
    • , Robert W. Finberg
    • , Evelyn A. Kurt-Jones
    •  & Jane E. Freedman
  • Research | | open

    Neutrophils play critical roles in the host response to bacteria, including the production neutrophil extracellular traps (NET). Here the authors show that NET formation in the context of pneumococcal meningitis impairs bacterial clearance and targeting NET formation in this context could be a potential therapeutic option.

    • Tirthankar Mohanty
    • , Jane Fisher
    • , Anahita Bakochi
    • , Ariane Neumann
    • , José Francisco Pereira Cardoso
    • , Christofer A. Q. Karlsson
    • , Chiara Pavan
    • , Iben Lundgaard
    • , Bo Nilson
    • , Peter Reinstrup
    • , Johan Bonnevier
    • , David Cederberg
    • , Johan Malmström
    • , Peter Bentzer
    •  & Adam Linder

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