Gout

Gout is a form of recurrent inflammatory arthritis caused by hyperuricaemia and subsequent accumulation of monosodium urate crystal deposition in the joints, tendons and surrounding tissues.

Latest Research and Reviews

  • Research | | open

    Masahiro Nakatochi et al. report a genome-wide meta-analysis of serum uric acid levels in the Japanese population. They identify 36 loci, including eight previously unreported loci, suggesting key cellular processes that contribute to elevated serum uric acid levels, which can lead to gout.

    • Masahiro Nakatochi
    • , Masahiro Kanai
    • , Akiyoshi Nakayama
    • , Asahi Hishida
    • , Yusuke Kawamura
    • , Sahoko Ichihara
    • , Masato Akiyama
    • , Hiroaki Ikezaki
    • , Norihiro Furusyo
    • , Seiko Shimizu
    • , Ken Yamamoto
    • , Makoto Hirata
    • , Rieko Okada
    • , Sayo Kawai
    • , Makoto Kawaguchi
    • , Yuichiro Nishida
    • , Chisato Shimanoe
    • , Rie Ibusuki
    • , Toshiro Takezaki
    • , Mayuko Nakajima
    • , Mikiya Takao
    • , Etsuko Ozaki
    • , Daisuke Matsui
    • , Takeshi Nishiyama
    • , Sadao Suzuki
    • , Naoyuki Takashima
    • , Yoshikuni Kita
    • , Kaori Endoh
    • , Kiyonori Kuriki
    • , Hirokazu Uemura
    • , Kokichi Arisawa
    • , Isao Oze
    • , Keitaro Matsuo
    • , Yohko Nakamura
    • , Haruo Mikami
    • , Takashi Tamura
    • , Hiroshi Nakashima
    • , Takahiro Nakamura
    • , Norihiro Kato
    • , Koichi Matsuda
    • , Yoshinori Murakami
    • , Tatsuaki Matsubara
    • , Mariko Naito
    • , Michiaki Kubo
    • , Yoichiro Kamatani
    • , Nariyoshi Shinomiya
    • , Mitsuhiro Yokota
    • , Kenji Wakai
    • , Yukinori Okada
    •  & Hirotaka Matsuo
  • Research | | open

    • Wei-Cheng Tseng
    • , Yung-Tai Chen
    • , Yao-Ping Lin
    • , Shuo-Ming Ou
    • , Chih-Yu Yang
    • , Chi-Hung Lin
    • , Der-Cherng Tarng
    • , Der-Cherng Tarng
    • , Wei-Cheng Tseng
    • , Ming-Tsun Tsai
    • , Shuo-Ming Ou
    • , Chih-Yu Yang
    • , Yao-Ping Lin
    • , Yu-Hsin Chen
    • , Yi-Fang Chuang
    • , Liang-Kung Chen
    • , Kwua-Yun Wang
    • , Chia-Jen Shih
    • , Yung-Tai Chen
    • , Yi-Sheng Lin
    • , Szu-Chun Hung
    • , Ko-Lin Kuo
    • , Tung-Po Hung
    • , Fen-Hsiang Hu
    • , Nien-Jung Chen
    • , Yu-Chi Chen
    • , Chi-Hung Lin
    • , Tung-Hu Tsai
    • , Shie-Liang Hsieh
    • , Yau-Huei Wei
    • , Chih-Cheng Hsu
    • , Jia-Sin Liu
    • , Yu-Kang Chang
    •  & Ming-Han Chiang
  • Reviews |

    In this Review, the authors summarize the results of genetics studies that confirm the importance of modulating urate levels in gout pathophysiology, and discuss how these discoveries could be applied to the treatment of hyperuricaemia and gout.

    • Tanya J. Major
    • , Nicola Dalbeth
    • , Eli A. Stahl
    •  & Tony R. Merriman

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