• Article |

    The number of primordial follicles, which constitute the ovarian reserve, decreases with age. By overexpressing a constitutively active version of the transcription factor FOXO3, the authors increase the ovarian reserve and fertility in aging female mice.

    • Emanuele Pelosi
    • , Shakib Omari
    • , Marc Michel
    • , Jun Ding
    • , Tomokazu Amano
    • , Antonino Forabosco
    • , David Schlessinger
    •  & Chris Ottolenghi
  • Article |

    The temporal opening and closing of cell–cell junctions at the blood–testis barrier allows the passage of immature germ cells during spermatogenesis. Su and colleagues identify a peptide fragment of the laminin-γ3 chain that disrupts the blood–testis barrier and reversibly impairs spermatogenesis in rats.

    • Linlin Su
    • , Dolores D. Mruk
    • , Pearl P.Y. Lie
    • , Bruno Silvestrini
    •  & C. Yan Cheng

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