Glycobiology

Glycobiology is the study of the structure, biosynthesis and biological functions of carbohydrates.

Featured

Latest Research and Reviews

News and Comment

  • News and Views |

    The biological functions of glycan motifs such as the Lewis blood antigens are often defined by their precise multivalent presentation on complex glycoconjugates, making synthesis particularly challenging. Access to a number of positionally defined Lewis motifs on natural polysaccharide scaffolds has now been achieved using bacterial glycosyltransferases.

    • Kun Huang
    •  & Sabine L Flitsch
    Nature Catalysis 2, 479-480
  • News and Views |

    Enzymatic approaches to synthesize oligosaccharides offer an alternative to chemical syntheses for the production of homogeneous glycans; however, enzyme-based routes typically require lengthy processes. Now, the design of a water-soluble affinity tag has enabled the automation of multistep enzymatic syntheses of mammalian oligosaccharides.

    • Nicola L. B. Pohl
    Nature Chemistry 11, 201-203
  • News and Views |

    Detailed biochemical, structural and growth studies reveal how Bacteroides thetaiotaomicron coordinates a complex enzymatic response to deconstruct pectins — complex dietary components that comprise a tremendous diversity of monosaccharide units and glycosidic linkage combinations.

    • Roderick I. Mackie
    •  & Isaac Cann
    Nature Microbiology 3, 127-129