Glomerulus

The glomerulus is a cluster of coiled capillaries at the beginning of each nephron, surrounded by the Bowman capsule. Blood entering the kidney through the afferent arteriole is filtered in the glomerulus, waste products and excess water drain into the proximal tubule, and cleansed blood exits via the efferent arteriole.

Latest Research and Reviews

  • Research | | open

    Sphingomyelin phosphodiesterase acid-like 3b (SMPDL3b) is a lipid raft enzyme known to affect membrane lipid composition. Here, Mitrofanova et al. show that increased expression of SMPDL3b in diabetes impairs insulin signaling and ceramide-1-phosphate (C1P) availability in podocytes, and that C1P supplementation protects mice from diabetic kidney disease.

    • A. Mitrofanova
    • , S. K. Mallela
    • , G. M. Ducasa
    • , T. H. Yoo
    • , E. Rosenfeld-Gur
    • , I. D. Zelnik
    • , J. Molina
    • , J. Varona Santos
    • , M. Ge
    • , A. Sloan
    • , J. J. Kim
    • , C. Pedigo
    • , J. Bryn
    • , I. Volosenco
    • , C. Faul
    • , Y. H. Zeidan
    • , C. Garcia Hernandez
    • , A. J. Mendez
    • , I. Leibiger
    • , G. W. Burke
    • , A. H. Futerman
    • , L. Barisoni
    • , Y. Ishimoto
    • , R. Inagi
    • , S. Merscher
    •  & A. Fornoni
  • Research | | open

    Kinase inhibitors used in chemotherapy are known for their adverse effects on kidney physiology. Here, Calizo et al. show that dasatinib is associated with a higher risk of glomerular toxicity compared to other kinase inhibitors, due to deleterious effects on cytoskeletal biomechanics in podocytes.

    • Rhodora C. Calizo
    • , Smiti Bhattacharya
    • , J. G. Coen van Hasselt
    • , Chengguo Wei
    • , Jenny S. Wong
    • , Robert J. Wiener
    • , Xuhua Ge
    • , Nicholas J. Wong
    • , Jia-Jye Lee
    • , Christina M. Cuttitta
    • , Gomathi Jayaraman
    • , Vivienne H. Au
    • , William Janssen
    • , Tong Liu
    • , Hong Li
    • , Fadi Salem
    • , Edgar A. Jaimes
    • , Barbara Murphy
    • , Kirk N. Campbell
    •  & Evren U. Azeloglu
  • Research | | open

    Estimated glomerular filtration rate (eGFR) is a measure of kidney function used to define chronic kidney disease. Here, Morris et al. perform trans-ethnic genome-wide meta-analyses for eGFR in 312,468 individuals and identify novel loci and downstream putative causal genes.

    • Andrew P. Morris
    • , Thu H. Le
    • , Haojia Wu
    • , Artur Akbarov
    • , Peter J. van der Most
    • , Gibran Hemani
    • , George Davey Smith
    • , Anubha Mahajan
    • , Kyle J. Gaulton
    • , Girish N. Nadkarni
    • , Adan Valladares-Salgado
    • , Niels Wacher-Rodarte
    • , Josyf C. Mychaleckyj
    • , Nicole D. Dueker
    • , Xiuqing Guo
    • , Yang Hai
    • , Jeffrey Haessler
    • , Yoichiro Kamatani
    • , Adrienne M. Stilp
    • , Gu Zhu
    • , James P. Cook
    • , Johan Ärnlöv
    • , Susan H. Blanton
    • , Martin H. de Borst
    • , Erwin P. Bottinger
    • , Thomas A. Buchanan
    • , Sylvia Cechova
    • , Fadi J. Charchar
    • , Pei-Lun Chu
    • , Jeffrey Damman
    • , James Eales
    • , Ali G. Gharavi
    • , Vilmantas Giedraitis
    • , Andrew C. Heath
    • , Eli Ipp
    • , Krzysztof Kiryluk
    • , Holly J. Kramer
    • , Michiaki Kubo
    • , Anders Larsson
    • , Cecilia M. Lindgren
    • , Yingchang Lu
    • , Pamela A. F. Madden
    • , Grant W. Montgomery
    • , George J. Papanicolaou
    • , Leslie J. Raffel
    • , Ralph L. Sacco
    • , Elena Sanchez
    • , Holger Stark
    • , Johan Sundstrom
    • , Kent D. Taylor
    • , Anny H. Xiang
    • , Aleksandra Zivkovic
    • , Lars Lind
    • , Erik Ingelsson
    • , Nicholas G. Martin
    • , John B. Whitfield
    • , Jianwen Cai
    • , Cathy C. Laurie
    • , Yukinori Okada
    • , Koichi Matsuda
    • , Charles Kooperberg
    • , Yii-Der Ida Chen
    • , Tatjana Rundek
    • , Stephen S. Rich
    • , Ruth J. F. Loos
    • , Esteban J. Parra
    • , Miguel Cruz
    • , Jerome I. Rotter
    • , Harold Snieder
    • , Maciej Tomaszewski
    • , Benjamin D. Humphreys
    •  & Nora Franceschini

News and Comment