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The transcriptional program underlying the origin of glial cells is unclear. Here the authors leverage single-cell/single-nucleus transcriptional and chromatin accessibility profiling to identify candidate cell fate specification genes and optimize a rapid astrocyte differentiation protocol.
Functional and transcriptomic comparison of primary neonatal, adult and ESC-derived astrocytes reveals major variations, highlighting the importance for an informed choice of astrocyte origin for research questions.
Oligodendrocyte precursor cells (OPCs) have functions beyond oligodendrogenesis. Here the authors show that OPCs can engulf thalamocortical presynapses in response to sensory experience in mice.
