Glial stem cells

Glial stem cells are self-renewing cells that have the capacity to produce some or all forms of glia.

Latest Research and Reviews

  • Research |

    There are no new oligodendrocytes in potentially remyelinated multiple sclerosis shadow plaques, although oligodendrocyte generation is increased in the normal appearing white matter of patients with aggressive disease, informing the development of new therapies.

    • Maggie S. Y. Yeung
    • , Mehdi Djelloul
    • , Embla Steiner
    • , Samuel Bernard
    • , Mehran Salehpour
    • , Göran Possnert
    • , Lou Brundin
    •  & Jonas Frisén
    Nature 566, 538-542
  • Research |

    Glioblastomas contains stem-like tumor cells that display differential metabolic profiles. Here the authors show that brain tumor initiating cells contain fragmented mitochondria owing to activation of the key mediator of mitochondrial fission, DRP1, controlled by a competitive CDK5–CAMK2 axis. Targeting DRP1 activity attenuates growth of stem-like tumor cells, and activated DRP1 informs poor patient prognosis.

    • Qi Xie
    • , Qiulian Wu
    • , Craig M Horbinski
    • , William A Flavahan
    • , Kailin Yang
    • , Wenchao Zhou
    • , Stephen M Dombrowski
    • , Zhi Huang
    • , Xiaoguang Fang
    • , Yu Shi
    • , Ashley N Ferguson
    • , David F Kashatus
    • , Shideng Bao
    •  & Jeremy N Rich
    Nature Neuroscience 18, 501-510

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