Germ cell tumours articles within Nature Communications

Featured

• Article
  11 August 2022 | Open Access

  Clonal diversification and histogenesis of malignant germ cell tumours

  The molecular characterisation of germ cell tumours (GCT) is necessary to understand their development and histological diversification. Here, the authors use whole-genome and transcriptome sequencing of GCTs across distinct histologies to reveal their somatic evolution and clonal diversification, as well as identify several putative biomarkers for treatment stratification.

  • Thomas R. W. Oliver
  • , Lia Chappell
  •  & Sam Behjati

• Article
  19 August 2021 | Open Access

  DMRT1-mediated reprogramming drives development of cancer resembling human germ cell tumors with features of totipotency

  The mechanisms by which in vivo expression of the Yamanaka transcription factors (OSKM) renders somatic cells permissive for differentiation remain unclear. Here, the authors show that in vivo reprogramming using OSKM generates germ cell tumors and drives acquisition of totipotency-like features in somatic cells through DMRT1.

  • Jumpei Taguchi
  • , Hirofumi Shibata
  •  & Yasuhiro Yamada

• Article
  20 December 2016 | Open Access

  Rare disruptive mutations in ciliary function genes contribute to testicular cancer susceptibility

  There is some evidence of a hereditary risk for developing testicular germ cell tumours. Here, the authors use whole-exome sequencing and identify a risk variant for the disease in DNAAF1, a gene involved in microtubule-based cilia.

  • Kevin Litchfield
  • , Max Levy
  •  & Clare Turnbull