Genomic analysis

Definition

Genomic analysis is the identification, measurement or comparison of genomic features such as DNA sequence, structural variation, gene expression, or regulatory and functional element annotation at a genomic scale. Methods for genomic analysis typically require high-throughput sequencing or microarray hybridization and bioinformatics.

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Latest Research and Reviews

  • Research | | open

    • Ekaterina Shvetsova
    • , Alina Sofronova
    • , Ramin Monajemi
    • , Kristina Gagalova
    • , Harmen H. M. Draisma
    • , Stefan J. White
    • , Gijs W. E. Santen
    • , Susana M. Chuva de Sousa Lopes
    • , Bastiaan T. Heijmans
    • , Joyce van Meurs
    • , Rick Jansen
    • , Lude Franke
    • , Szymon M. Kiełbasa
    • , Johan T. den Dunnen
    • , Peter A. C. ‘t Hoen
    • , Bastiaan T Heijmans
    • , Peter AC ’t Hoen
    • , Joyce van Meurs
    • , Dorret I Boomsma
    • , René Pool
    • , Jenny van Dongen
    • , Jouke J Hottenga
    • , Marleen MJ van Greevenbroek
    • , Coen DA Stehouwer
    • , Carla JH van der Kallen
    • , Casper G Schalkwijk
    • , Cisca Wijmenga
    • , Sasha Zhernakova
    • , Ettje F Tigchelaar
    • , P Eline Slagboom
    • , Marian Beekman
    • , Joris Deelen
    • , Diana van Heemst
    • , Jan H Veldink
    • , Leonard H van den Berg
    • , Cornelia M van Duijn
    • , Bert A Hofman
    • , André G Uitterlinden
    • , P Mila Jhamai
    • , Michael Verbiest
    • , H Eka D Suchiman
    • , Marijn Verkerk
    • , Ruud van der Breggen
    • , Jeroen van Rooij
    • , Nico Lakenberg
    • , Hailiang Mei
    • , Jan Bot
    • , Dasha V Zhernakova
    • , Peter van ’t Hof
    • , Patrick Deelen
    • , Irene Nooren
    • , Matthijs Moed
    • , Martijn Vermaat
    • , René Luijk
    • , Marc Jan Bonder
    • , Maarten van Iterson
    • , Freerk van Dijk
    • , Michiel van Galen
    • , Wibowo Arindrarto
    • , Szymon M Kiełbasa
    • , Morris A Swertz
    • , Erik W van Zwet
    • , Aaron Isaacs
    • , Rick Jansen
    • , Lude Franke
    • , LC Francioli
    • , A Menelaou
    • , SL Pulit
    • , F van Dijk
    • , PF Palamara
    • , CC Elbers
    • , PB Neerincx
    • , K Ye
    • , V Guryev
    • , WP Kloosterman
    • , P Deelen
    • , A Abdellaoui
    • , EM van Leeuwen
    • , M van Oven
    • , M Vermaat
    • , M Li
    • , JF Laros
    • , LC Karssen
    • , A Kanterakis
    • , N Amin
    • , JJ Hottenga
    • , EW Lameijer
    • , M Kattenberg
    • , M Dijkstra
    • , H Byelas
    • , J van Setten
    • , BD van Schaik
    • , J Bot
    • , IJ Nijman
    • , I Renkens
    • , T Marschall
    • , A Schönhuth
    • , JY Hehir-Kwa
    • , RE Handsaker
    • , P Polak
    • , M Sohail
    • , D Vuzman
    • , F Hormozdiari
    • , D van Enckevort
    • , H Mei
    • , V Koval
    • , MH Moed
    • , KJ van der Velde
    • , F Rivadeneira
    • , K Estrada
    • , C Medina-Gomez
    • , A Isaacs
    • , SA McCarroll
    • , M Beekman
    • , AJ de Craen
    • , HE Suchiman
    • , BA Hofman
    • , B Oostra
    • , AG Uitterlinden
    • , G Willemsen
    • , M Platteel
    • , JH Veldink
    • , LH van den Berg
    • , SJ Pitts
    • , S Potluri
    • , P Sundar
    • , DR Cox
    • , SR Sunyaev
    • , JT den Dunnen
    • , M Stoneking
    • , P de Knijff
    • , M Kayser
    • , Q Li
    • , Y Li
    • , Y Du
    • , R Chen
    • , H Cao
    • , N Li
    • , S Cao
    • , J Wang
    • , JA Bovenberg
    • , I Pe’er
    • , PE Slagboom
    • , CM van Duijn
    • , DI Boomsma
    • , GJ van Ommen
    • , PI de Bakker
    • , MA Swertz
    •  & C Wijmenga
  • Reviews |

    This Review discusses causal germline variants in prostate cancer identified through genome-wide association studies (GWAS) and post-GWAS analyses. The latter are vital to identify causal variants and molecular mechanisms by which these variants promote prostate tumorigenesis, with potential clinical applications.

    • Samaneh Farashi
    • , Thomas Kryza
    • , Judith Clements
    •  & Jyotsna Batra
  • Research | | open

    Acne vulgaris is a chronic inflammation of the skin, the genetic basis of which is incompletely understood. Here, Petridis et al. perform GWAS and meta-analysis for acne in 26,722 individuals and identify 12 novel risk loci that implicate structure and maintenance of the skin in severe acne risk.

    • Christos Petridis
    • , Alexander A. Navarini
    • , Nick Dand
    • , Jake Saklatvala
    • , David Baudry
    • , Michael Duckworth
    • , Michael H. Allen
    • , Charles J. Curtis
    • , Sang Hyuck Lee
    • , A. David Burden
    • , Alison Layton
    • , Veronique Bataille
    • , Andrew E. Pink
    • , Anton Alexandroff
    • , Alex Anstey
    • , Jaskiran Azad
    • , Omar Aziz
    • , Nigel Burrows
    • , Aamir Butt
    • , Peter Cartwright
    • , Anna Chapman
    • , Timothy H. Clayton
    • , Sandeep Cliff
    • , Tim Cutler
    • , Brigid Daly
    • , Amrit Darvay
    • , Claudia DeGiovanni
    • , Anthony Downs
    • , Colm Dwyer
    • , John English
    • , Adam Ferguson
    • , Colin Fleming
    • , Elizabeth Fraser-Andrews
    • , Mark Goodfield
    • , Clive E. Grattan
    • , Hartmut Hempel
    • , Sue Hood
    • , Bronwyn Hughes
    • , Evmorfia Ladoyanni
    • , Calum Lyon
    • , Ali Mahmud
    • , Moshin Malik
    • , Eleanor Mallon
    • , Simon Meggitt
    • , Andrew Messenger
    • , Yaaseen Moosa
    • , Stephanie Munn
    • , Anthony Ormerod
    • , Deepak Rallan
    • , Janet Ross
    • , Ingrid Salvary
    • , Rachel Wachsmuth
    • , Shyamal Wahie
    • , Shernaz Walton
    • , Sarah Walsh
    • , Diane Williamson
    • , Carolyn Willis
    • , Isabelle Carlavan
    • , Johannes J. Voegel
    • , Timothy D. Spector
    • , Richard C. Trembath
    • , John A. McGrath
    • , Catherine H. Smith
    • , Jonathan N. Barker
    •  & Michael A. Simpson

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