Genome

Definition

The genome is the full genetic complement of an organism, encoded in either DNA or, in many viruses, RNA. It includes both the genes and non-coding sequences.

Featured

Latest Research and Reviews

  • Research | | open

    The structural basis of RNA-based gene control offers the possibility of de novo design. Here the authors present a computational design approach for Small Transcription Activating RNAs a bacterial RNA regulator that allows for versatile and dynamic control of genes, pathways and genetic circuits.

    • James Chappell
    • , Alexandra Westbrook
    • , Matthew Verosloff
    •  & Julius B. Lucks
  • Research | | open

    Barnyardgrass is a problematic agricultural weed. Here, via genomic analysis, Guo et al. identify genes potentially underlying its success, including a gene cluster activated in response to co-cultivation with rice that leads to synthesis of the allelochemical DIMBOA.

    • Longbiao Guo
    • , Jie Qiu
    • , Chuyu Ye
    • , Gulei Jin
    • , Lingfeng Mao
    • , Haiqiang Zhang
    • , Xuefang Yang
    • , Qiong Peng
    • , Yingying Wang
    • , Lei Jia
    • , Zhangxiang Lin
    • , Gengmi Li
    • , Fei Fu
    • , Chen Liu
    • , Li Chen
    • , Enhui Shen
    • , Weidi Wang
    • , Qinjie Chu
    • , Dongya Wu
    • , Sanling Wu
    • , Chenyang Xia
    • , Yongfei Zhang
    • , Xiaomao Zhou
    • , Lifeng Wang
    • , Lamei Wu
    • , Weijie Song
    • , Yunfei Wang
    • , Qingyao Shu
    • , Daisuke Aoki
    • , Emi Yumoto
    • , Takao Yokota
    • , Koji Miyamoto
    • , Kazunori Okada
    • , Do-Soon Kim
    • , Daguang Cai
    • , Chulong Zhang
    • , Yonggen Lou
    • , Qian Qian
    • , Hirofumi Yamaguchi
    • , Hisakazu Yamane
    • , Chui-Hua Kong
    • , Michael P. Timko
    • , Lianyang Bai
    •  & Longjiang Fan
  • Research | | open

    People of Mexico have diverse historical and genetic background. Here, Romero-Hidalgo and colleagues sequence whole genomes of Native Americans of Mexico, and show demographic history and genetic variation shared among subgroups of Native Americans.

    • Sandra Romero-Hidalgo
    • , Adrián Ochoa-Leyva
    • , Alejandro Garcíarrubio
    • , Victor Acuña-Alonzo
    • , Erika Antúnez-Argüelles
    • , Martha Balcazar-Quintero
    • , Rodrigo Barquera-Lozano
    • , Alessandra Carnevale
    • , Fernanda Cornejo-Granados
    • , Juan Carlos Fernández-López
    • , Rodrigo García-Herrera
    • , Humberto García-Ortíz
    • , Ángeles Granados-Silvestre
    • , Julio Granados
    • , Fernando Guerrero-Romero
    • , Enrique Hernández-Lemus
    • , Paola León-Mimila
    • , Gastón Macín-Pérez
    • , Angélica Martínez-Hernández
    • , Marta Menjivar
    • , Enrique Morett
    • , Lorena Orozco
    • , Guadalupe Ortíz-López
    • , Fernando Pérez-Villatoro
    • , Javier Rivera-Morales
    • , Fernando Riveros-McKay
    • , Marisela Villalobos-Comparán
    • , Hugo Villamil-Ramírez
    • , Teresa Villarreal-Molina
    • , Samuel Canizales-Quinteros
    •  & Xavier Soberón
  • Research | | open

    Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder with symptoms including intrusive thoughts and time-consuming repetitive behaviors. Here Noh and colleagues identify genes enriched for functional variants associated with increased risk of OCD.

    • Hyun Ji Noh
    • , Ruqi Tang
    • , Jason Flannick
    • , Colm O’Dushlaine
    • , Ross Swofford
    • , Daniel Howrigan
    • , Diane P. Genereux
    • , Jeremy Johnson
    • , Gerard van Grootheest
    • , Edna Grünblatt
    • , Erik Andersson
    • , Diana R. Djurfeldt
    • , Paresh D. Patel
    • , Michele Koltookian
    • , Christina M. Hultman
    • , Michele T. Pato
    • , Carlos N. Pato
    • , Steven A. Rasmussen
    • , Michael A. Jenike
    • , Gregory L. Hanna
    • , S. Evelyn Stewart
    • , James A. Knowles
    • , Stephan Ruhrmann
    • , Hans-Jörgen Grabe
    • , Michael Wagner
    • , Christian Rück
    • , Carol A. Mathews
    • , Susanne Walitza
    • , Daniëlle C. Cath
    • , Guoping Feng
    • , Elinor K. Karlsson
    •  & Kerstin Lindblad-Toh

News and Comment