Chromosomal inversions that relocate a limb enhancer establish patterns of asymmetric chromatin contacts, so-called architectural stripes, that result in ectopic gene expression and congenital limb phenotypes, according to a study in Nature Cell Biology.

Three studies provide new insights into the mechanisms responsible for genome remodelling and changes in gene expression associated with senescence.

A new study uses deep learning to predict genetic variants that generate cryptic splice sites and to investigate the role of these non-coding cryptic splice mutations in rare genetic disorders.

Single-cell allelic expression analysis reveals that enhancers predominantly modulate the frequency of transcription bursts whereas core promoters affect their size.

A plant complex comprising SUVH1, SUVH3, DNAJ1 and DNAJ2 counteracts DNA-methylation-mediated silencing of transposon-neighbouring genes.