Genome-wide association studies

Genome-wide association studies (GWASs) are unbiased genome screens of unrelated individuals and appropriately matched controls or parent-affected child trios to establish whether any genetic variant is associated with a trait. These studies typically focus on associations between single-nucleotide polymorphisms (SNPs) and major diseases.

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  • Research |

    • Kazuki Takeda
    • , Ikuyo Kou
    • , Nao Otomo
    • , Anna Grauers
    • , Yan-Hui Fan
    • , Yoji Ogura
    • , Yohei Takahashi
    • , Yukihide Momozawa
    • , Elisabet Einarsdottir
    • , Juha Kere
    • , Noriaki Kawakami
    • , Taichi Tsuji
    • , Koki Uno
    • , Teppei Suzuki
    • , Manabu Ito
    • , Shohei Minami
    • , Toshiaki Kotani
    • , Tsuyoshi Sakuma
    • , Haruhisa Yanagida
    • , Hiroshi Taneichi
    • , Ikuho Yonezawa
    • , Hideki Sudo
    • , Kazuhiro Chiba
    • , Naobumi Hosogane
    • , Kotaro Nishida
    • , Kenichiro Kakutani
    • , Tsutomu Akazawa
    • , Takashi Kaito
    • , Kei Watanabe
    • , Katsumi Harimaya
    • , Yuki Taniguchi
    • , Hideki Shigematsu
    • , Satoru Demura
    • , Takahiro Iida
    • , Katsuki Kono
    • , Eijiro Okada
    • , Nobuyuki Fujita
    • , Mitsuru Yagi
    • , Morio Matsumoto
    • , Yong Qiu
    • , You-Qiang Song
    • , Paul Gerdhem
    • , Kota Watanabe
    •  & Shiro Ikegawa
  • Research | | open

    The burden of asthma varies between ancestries, but GWAS have so far focused on mainly European ancestry populations. Here, Daya et al. perform GWAS for asthma in 14,654 individuals of African ancestry and, besides confirming previously known loci, identify two potentially African ancestry-specific loci.

    • Michelle Daya
    • , Nicholas Rafaels
    • , Tonya M. Brunetti
    • , Sameer Chavan
    • , Albert M. Levin
    • , Aniket Shetty
    • , Christopher R. Gignoux
    • , Meher Preethi Boorgula
    • , Genevieve Wojcik
    • , Monica Campbell
    • , Candelaria Vergara
    • , Dara G. Torgerson
    • , Victor E. Ortega
    • , Ayo Doumatey
    • , Henry Richard Johnston
    • , Nathalie Acevedo
    • , Maria Ilma Araujo
    • , Pedro C. Avila
    • , Gillian Belbin
    • , Eugene Bleecker
    • , Carlos Bustamante
    • , Luis Caraballo
    • , Alvaro Cruz
    • , Georgia M. Dunston
    • , Celeste Eng
    • , Mezbah U. Faruque
    • , Trevor S. Ferguson
    • , Camila Figueiredo
    • , Jean G. Ford
    • , Weiniu Gan
    • , Pierre-Antoine Gourraud
    • , Nadia N. Hansel
    • , Ryan D. Hernandez
    • , Edwin Francisco Herrera-Paz
    • , Silvia Jiménez
    • , Eimear E. Kenny
    • , Jennifer Knight-Madden
    • , Rajesh Kumar
    • , Leslie A. Lange
    • , Ethan M. Lange
    • , Antoine Lizee
    • , Pissamai Maul
    • , Trevor Maul
    • , Alvaro Mayorga
    • , Deborah Meyers
    • , Dan L. Nicolae
    • , Timothy D. O’Connor
    • , Ricardo Riccio Oliveira
    • , Christopher O. Olopade
    • , Olufunmilayo Olopade
    • , Zhaohui S. Qin
    • , Charles Rotimi
    • , Nicolas Vince
    • , Harold Watson
    • , Rainford J. Wilks
    • , James G. Wilson
    • , Steven Salzberg
    • , Carole Ober
    • , Esteban G. Burchard
    • , L. Keoki Williams
    • , Terri H. Beaty
    • , Margaret A. Taub
    • , Ingo Ruczinski
    • , Rasika A. Mathias
    • , Kathleen C. Barnes
    • , Ayola Akim Adegnika
    • , Ganiyu Arinola
    • , Ulysse Ateba-Ngoa
    • , Gerardo Ayestas
    • , Hilda Bjarnadóttir
    • , Adolfo Correa
    • , Said Omar Leiva Erazo
    • , Marilyn G. Foreman
    • , Cassandra Foster
    • , Li Gao
    • , Jingjing Gao
    • , Leslie Grammer
    • , Mark Hansen
    • , Tina Hartert
    • , Yijuan Hu
    • , Iain Königsberg
    • , Kwang-Youn A. Kim
    • , Pamela Landaverde-Torres
    • , Javier Marrugo
    • , Beatriz Martinez
    • , Rosella Martinez
    • , Luis F. Mayorga
    • , Delmy-Aracely Mejia-Mejia
    • , Catherine Meza
    • , Solomon Musani
    • , Shaila Musharoff
    • , Oluwafemi Oluwole
    • , Maria Pino-Yanes
    • , Hector Ramos
    • , Allan Saenz
    • , Maureen Samms-Vaughan
    • , Robert Schleimer
    • , Alan F. Scott
    • , Suyash S. Shringarpure
    • , Wei Song
    • , Zachary A. Szpiech
    • , Raul Torres
    • , Gloria Varela
    • , Olga Marina Vasquez
    • , Francisco M. De La Vega
    • , Lorraine B. Ware
    •  & Maria Yazdanbakhsh
  • Research | | open

    • Maya S. Safarova
    • , Benjamin A. Satterfield
    • , Xiao Fan
    • , Erin E. Austin
    • , Zhan Ye
    • , Lisa Bastarache
    • , Neil Zheng
    • , Marylyn D. Ritchie
    • , Kenneth M. Borthwick
    • , Marc S. Williams
    • , Eric B. Larson
    • , Aaron Scrol
    • , Gail P. Jarvik
    • , David R. Crosslin
    • , Kathleen Leppig
    • , Laura J. Rasmussen-Torvik
    • , Sarah A. Pendergrass
    • , Amy C. Sturm
    • , Bahram Namjou
    • , Amy Sanghavi Shah
    • , Robert J. Carroll
    • , Wendy K. Chung
    • , Wei-Qi Wei
    • , QiPing Feng
    • , C. Michael Stein
    • , Dan M. Roden
    • , Teri A. Manolio
    • , Daniel J. Schaid
    • , Joshua C. Denny
    • , Scott J. Hebbring
    • , Mariza de Andrade
    •  & Iftikhar J. Kullo

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