Genome assembly algorithms

Definition

Genome assembly algorithms are sets of well defined procedures for reconstructing DNA sequences from large numbers of shorter DNA sequence fragments. Fragments are aligned against one another and overlapping sections are identified and merged.

Latest Research and Reviews

  • Research | | open

    The assembly of the durian genome provides insights into the unique flavor profile of this tropical fruit. Transcriptome and metabolome analyses show that methionine γ-lyase is upregulated and that volatile sulfur compounds are produced during ripening.

    • Bin Tean Teh
    • , Kevin Lim
    • , Chern Han Yong
    • , Cedric Chuan Young Ng
    • , Sushma Ramesh Rao
    • , Vikneswari Rajasegaran
    • , Weng Khong Lim
    • , Choon Kiat Ong
    • , Ki Chan
    • , Vincent Kin Yuen Cheng
    • , Poh Sheng Soh
    • , Sanjay Swarup
    • , Steven G Rozen
    • , Niranjan Nagarajan
    •  & Patrick Tan
    Nature Genetics 49, 1633–1641
  • Research |

    Assembly of polyploid plant genomes has been technically challenging. Now, a study presents a half haplotype-resolved hexaploid genome of sweet potato, Ipomoea batatas, using a novel haplotyping method.

    • Jun Yang
    • , M-Hossein Moeinzadeh
    • , Heiner Kuhl
    • , Johannes Helmuth
    • , Peng Xiao
    • , Stefan Haas
    • , Guiling Liu
    • , Jianli Zheng
    • , Zhe Sun
    • , Weijuan Fan
    • , Gaifang Deng
    • , Hongxia Wang
    • , Fenhong Hu
    • , Shanshan Zhao
    • , Alisdair R. Fernie
    • , Stefan Boerno
    • , Bernd Timmermann
    • , Peng Zhang
    •  & Martin Vingron
    Nature Plants 3, 696–703
  • Research | | open

    A report of high-depth, short-read sequencing and de novo assemblies for 150 individuals from 50 parent–offspring trios as part of establishing a population reference genome for the GenomeDenmark project.

    • Lasse Maretty
    • , Jacob Malte Jensen
    • , Bent Petersen
    • , Jonas Andreas Sibbesen
    • , Siyang Liu
    • , Palle Villesen
    • , Laurits Skov
    • , Kirstine Belling
    • , Christian Theil Have
    • , Jose M. G. Izarzugaza
    • , Marie Grosjean
    • , Jette Bork-Jensen
    • , Jakob Grove
    • , Thomas D. Als
    • , Shujia Huang
    • , Yuqi Chang
    • , Ruiqi Xu
    • , Weijian Ye
    • , Junhua Rao
    • , Xiaosen Guo
    • , Jihua Sun
    • , Hongzhi Cao
    • , Chen Ye
    • , Johan van Beusekom
    • , Thomas Espeseth
    • , Esben Flindt
    • , Rune M. Friborg
    • , Anders E. Halager
    • , Stephanie Le Hellard
    • , Christina M. Hultman
    • , Francesco Lescai
    • , Shengting Li
    • , Ole Lund
    • , Peter Løngren
    • , Thomas Mailund
    • , Maria Luisa Matey-Hernandez
    • , Ole Mors
    • , Christian N. S. Pedersen
    • , Thomas Sicheritz-Pontén
    • , Patrick Sullivan
    • , Ali Syed
    • , David Westergaard
    • , Rachita Yadav
    • , Ning Li
    • , Xun Xu
    • , Torben Hansen
    • , Anders Krogh
    • , Lars Bolund
    • , Thorkild I. A. Sørensen
    • , Oluf Pedersen
    • , Ramneek Gupta
    • , Simon Rasmussen
    • , Søren Besenbacher
    • , Anders D. Børglum
    • , Jun Wang
    • , Hans Eiberg
    • , Karsten Kristiansen
    • , Søren Brunak
    •  & Mikkel Heide Schierup
    Nature 548, 87–91

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