Genetics

Definition

Genetics is the branch of science concerned with genes, heredity, and variation in living organisms. It seeks to understand the process of trait inheritance from parents to offspring, including the molecular structure and function of genes, gene behaviour in the context of a cell or organism (e.g. dominance and epigenetics), gene distribution, and variation and change in populations.

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Latest Research and Reviews

  • Reviews |

    New technological advances in genomics have enabled the rapid discovery of hundreds of gene mutations linked to epilepsy. This Review considers the prospects for precision medicine in genetic epilepsies, the use of conventional and novel experimental models to unpick the complex pathogenic mechanisms of these diseases and the opportunities and challenges that face basic and clinical researchers.

    • Scott T. Demarest
    •  & Amy Brooks-Kayal
  • Reviews |

    PIWI-interacting RNAs (piRNAs) have numerous crucial biological roles, particularly transposon silencing in the germ line. In this Review, the authors describe our latest understanding of piRNA biogenesis and functions across diverse species, highlighting how, despite the universal importance of transposon control, different species have evolved intriguingly distinct mechanistic routes to achieve this.

    • Deniz M. Ozata
    • , Ildar Gainetdinov
    • , Ansgar Zoch
    • , Dónal O’Carroll
    •  & Phillip D. Zamore
  • Protocols |

    This protocol describes procedures for speed-breeding approaches using growth cabinets and LED-supplemented glasshouses. The approaches can be used to accelerate crop research and are compatible with a wide variety of crops.

    • Sreya Ghosh
    • , Amy Watson
    • , Oscar E. Gonzalez-Navarro
    • , Ricardo H. Ramirez-Gonzalez
    • , Luis Yanes
    • , Marcela Mendoza-Suárez
    • , James Simmonds
    • , Rachel Wells
    • , Tracey Rayner
    • , Phon Green
    • , Amber Hafeez
    • , Sadiye Hayta
    • , Rachel E. Melton
    • , Andrew Steed
    • , Abhimanyu Sarkar
    • , Jeremy Carter
    • , Lionel Perkins
    • , John Lord
    • , Mark Tester
    • , Anne Osbourn
    • , Matthew J. Moscou
    • , Paul Nicholson
    • , Wendy Harwood
    • , Cathie Martin
    • , Claire Domoney
    • , Cristobal Uauy
    • , Brittany Hazard
    • , Brande B. H. Wulff
    •  & Lee T. Hickey
  • Reviews |

    Fungi are enormously diverse, not the least in potential genetic markers that can be used for high-throughput sequencing studies of the mycobiome. In this Review, Nilsson and colleagues provide advice for leveraging next-generation technologies to explore mycobiome diversity in different habitats.

    • R. Henrik Nilsson
    • , Sten Anslan
    • , Mohammad Bahram
    • , Christian Wurzbacher
    • , Petr Baldrian
    •  & Leho Tedersoo
  • Research | | open

    An improved, fully re-annotated Aedes aegypti genome assembly (AaegL5) provides insights into the sex-determining M locus, chemosensory systems that help mosquitoes to hunt humans and loci involved in insecticide resistance and will help to generate intervention strategies to fight this deadly disease vector.

    • Benjamin J. Matthews
    • , Olga Dudchenko
    • , Sarah B. Kingan
    • , Sergey Koren
    • , Igor Antoshechkin
    • , Jacob E. Crawford
    • , William J. Glassford
    • , Margaret Herre
    • , Seth N. Redmond
    • , Noah H. Rose
    • , Gareth D. Weedall
    • , Yang Wu
    • , Sanjit S. Batra
    • , Carlos A. Brito-Sierra
    • , Steven D. Buckingham
    • , Corey L. Campbell
    • , Saki Chan
    • , Eric Cox
    • , Benjamin R. Evans
    • , Thanyalak Fansiri
    • , Igor Filipović
    • , Albin Fontaine
    • , Andrea Gloria-Soria
    • , Richard Hall
    • , Vinita S. Joardar
    • , Andrew K. Jones
    • , Raissa G. G. Kay
    • , Vamsi K. Kodali
    • , Joyce Lee
    • , Gareth J. Lycett
    • , Sara N. Mitchell
    • , Jill Muehling
    • , Michael R. Murphy
    • , Arina D. Omer
    • , Frederick A. Partridge
    • , Paul Peluso
    • , Aviva Presser Aiden
    • , Vidya Ramasamy
    • , Gordana Rašić
    • , Sourav Roy
    • , Karla Saavedra-Rodriguez
    • , Shruti Sharan
    • , Atashi Sharma
    • , Melissa Laird Smith
    • , Joe Turner
    • , Allison M. Weakley
    • , Zhilei Zhao
    • , Omar S. Akbari
    • , William C. Black IV
    • , Han Cao
    • , Alistair C. Darby
    • , Catherine A. Hill
    • , J. Spencer Johnston
    • , Terence D. Murphy
    • , Alexander S. Raikhel
    • , David B. Sattelle
    • , Igor V. Sharakhov
    • , Bradley J. White
    • , Li Zhao
    • , Erez Lieberman Aiden
    • , Richard S. Mann
    • , Louis Lambrechts
    • , Jeffrey R. Powell
    • , Maria V. Sharakhova
    • , Zhijian Tu
    • , Hugh M. Robertson
    • , Carolyn S. McBride
    • , Alex R. Hastie
    • , Jonas Korlach
    • , Daniel E. Neafsey
    • , Adam M. Phillippy
    •  & Leslie B. Vosshall
    Nature, 1–7

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