Genetics

Genetics is the branch of science concerned with genes, heredity, and variation in living organisms. It seeks to understand the process of trait inheritance from parents to offspring, including the molecular structure and function of genes, gene behaviour in the context of a cell or organism (e.g. dominance and epigenetics), gene distribution, and variation and change in populations.

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Latest Research and Reviews

  • Research
    | Open Access

    • Eva Rye Rasmussen
    • , Pär Hallberg
    • , Ekaterina V. Baranova
    • , Niclas Eriksson
    • , Malgorzata Karawajczyk
    • , Caroline Johansson
    • , Marco Cavalli
    • , Cyrielle Maroteau
    • , Abirami Veluchamy
    • , Gunilla Islander
    • , Svante Hugosson
    • , Ingrid Terreehorst
    • , Folkert W. Asselbergs
    • , Pia Norling
    • , Hans-Erik Johansson
    • , Hugo Kohnke
    • , Ann-Christine Syvänen
    • , Moneeza K. Siddiqui
    • , Chim C. Lang
    • , Patrik K. E. Magnusson
    • , Qun-Ying Yue
    • , Claes Wadelius
    • , Christian von Buchwald
    • , Anette Bygum
    • , Ana Alfirevic
    • , Anke H. Maitland-van der Zee
    • , Colin N. A. Palmer
    •  & Mia Wadelius
  • Research
    | Open Access

    Loss ofMEN1 results in an inherited multiple endocrine neoplastic type 1 syndrome. Here, the authors generate an alveolar type II cell MEN1 knockout mouse model and show that on a Kras mutant background the mice develop lung tumors with features of neuroendocrine differentiation.

    • Huan Qiu
    • , Bang-Ming Jin
    • , Zhan-Feng Wang
    • , Bin Xu
    • , Qi-Fan Zheng
    • , Li Zhang
    • , Ling-Yu Zhu
    • , Shuang Shi
    • , Jun-Bo Yuan
    • , Xiao Lin
    • , Shu-Bin Gao
    •  & Guang-Hui Jin
  • Research
    | Open Access

    Although there is extensive theory predicting the effects of population bottlenecks on mutation load, there is little empirical evidence from recent bottlenecks. Here, Grossen et al. compare the consequences of population bottlenecks in six ibex species for genome-wide variation and mutation load.

    • Christine Grossen
    • , Frédéric Guillaume
    • , Lukas F. Keller
    •  & Daniel Croll
  • Research
    | Open Access

    Adult forms of inflammatory bowel disease (IBD) are of a polygenic nature, but paediatric and very early onset (VEO) IBD also occur as monogenic forms. Here, using whole exome sequencing, the authors explore both the monogenic and polygenic contribution to VEO-IBD and characterize a rare somatic mosaic VEO-IBD patient.

    • Eva Gonçalves Serra
    • , Tobias Schwerd
    • , Loukas Moutsianas
    • , Athena Cavounidis
    • , Laura Fachal
    • , Sumeet Pandey
    • , Jochen Kammermeier
    • , Nicholas M. Croft
    • , Carsten Posovszky
    • , Astor Rodrigues
    • , Richard K. Russell
    • , Farah Barakat
    • , Marcus K. H. Auth
    • , Robert Heuschkel
    • , Matthias Zilbauer
    • , Krzysztof Fyderek
    • , Christian Braegger
    • , Simon P. Travis
    • , Jack Satsangi
    • , Miles Parkes
    • , Nikhil Thapar
    • , Helen Ferry
    • , Julie C. Matte
    • , Kimberly C. Gilmour
    • , Andrzej Wedrychowicz
    • , Peter Sullivan
    • , Carmel Moore
    • , Jennifer Sambrook
    • , Willem Ouwehand
    • , David Roberts
    • , John Danesh
    • , Toni A. Baeumler
    • , Tudor A. Fulga
    • , Mohammad Karaminejadranjbar
    • , Ahmed Ahmed
    • , Rachel Wilson
    • , Jeffrey C. Barrett
    • , Abdul Elkadri
    • , Anne M. Griffiths
    • , Marlen Zurek
    • , Caterina Strisciuglio
    • , Mamoun Elawad
    • , Bernice Lo
    • , Carolina Arancibia-Carcamo
    • , Adam Bailey
    • , Ellie Barnes
    • , Elizabeth Louise Bird-Lieberman
    • , Oliver Brain
    • , Barbara Braden
    • , Jane Collier
    • , James East
    • , Lucy Howarth
    • , Satish Keshav
    • , Paul Klenerman
    • , Simon Leedham
    • , Rebecca Palmer
    • , Fiona Powrie
    • , Alison Simmons
    • , Matthew Walker
    • , Zoe Tolkien
    • , Stephen Kaptoge
    • , David Allen
    • , Susan Mehenny
    • , Jonathan Mant
    • , Emanuele Di Angelantonio
    • , Simon G. Thompson
    • , Bahtiyar Yilmaz
    • , Pascal Juillerat
    • , Markus Geuking
    • , Reiner Wiest
    • , Andrew J. Macpherson
    • , Francisco Damian Bravo
    • , Lukas Brügger
    • , Ove Carstens
    • , Ulrike Graf Bigler
    • , Benjamin Heimgartner
    • , Monica Rusticeanu
    • , Sybille Schmid (-Uebelhart)
    • , Bruno Strebel
    • , Aurora Tatu
    • , Radu Tutuian
    • , Reiner Wiest
    • , Ove Øyås
    • , Charlotte Ramon
    • , Jörg Stelling
    • , Yannick Franc
    • , Nicolas Fournier
    • , Valerie E. H. Pittet
    • , Bernard Burnand
    • , Mara Egger
    • , Yannick Franc
    • , Delphine Golay
    • , Astrid Marot
    • , Leilla Musso
    • , Valérie Pittet
    • , Jean-Benoît Rossel
    • , Vivianne Seematter
    • , Joachim Sommer
    • , Rachel Vulliamy
    • , Pierre Michetti
    • , Michel H. Maillard
    • , Céline Keller
    • , Michel H. Maillard
    • , Andreas Nydegger
    • , Alain Schoepfe
    • , Eva Archanioti
    • , Jessica Ezri
    • , Montserrat Fraga
    • , Alain Schoepfer
    • , Christoph Müller
    • , Gerhard Rogler
    • , Luc Biedermann
    • , Mirjam Blattmann
    • , Sabine Burk
    • , Barbara Dora
    • , Michael Fried
    • , Benjamin Misselwitz
    • , Beat Müllhaupt
    • , Nicole Obialo
    • , Daniel Pohl
    • , Nadia Raschle
    • , Gerhard Rogler
    • , Michael Scharl
    • , Stephan Vavricka
    • , Roland Von Känel
    • , Jonas Zeitz
    • , Karim Abdelrahman
    • , Gentiana Ademi
    • , Jan Borovicka
    • , Stephan Brand
    • , Remus Frei
    • , Johannes Haarer
    • , Christina Knellwolf (-Grieger)
    • , Claudia Krieger(-Grübel)
    • , Patrizia Künzler
    • , Christa Meyenberger
    • , Pamela Meyer
    • , Nina Röhrich
    • , Mikael Sawatzki
    • , Martin Schelling
    • , Gian-Marco Semadeni
    • , Michael Sulz
    • , Dorothee Zimmermann
    • , Patrick Aepli
    • , Dominique H. Criblez
    • , Cyrill Hess
    • , Jean-Pierre Richterich
    • , Johannes Spalinger
    • , Dominic Staudenmann
    • , Andreas Stulz
    • , Stefanie Wöhrle
    • , Amman Thomas
    • , Claudia Anderegg
    • , Henrik Köhler
    • , Rachel Kusche
    • , Anca-Teodora Antonino
    • , Eviano Arrigoni
    • , José M. Bengoa
    • , Sophie Cunningham
    • , Philippe de Saussure
    • , Laurent Girard
    • , Diana Bakker de Jong
    • , Polat Bastürk
    • , Simon Brunner
    • , Lukas Degen
    • , Petr Hruz
    • , Carolina Khalid-de Bakker
    • , Jan Niess
    • , Bruno Balsiger
    • , Janine Haldemann
    • , Gaby Saner
    • , Frank Seibold
    • , Peter Bauerfeind
    • , Andrea Becocci
    • , Dominique Belli
    • , Janek Binek
    • , Peter Hengstler
    • , Stephan Boehm
    • , Tujana Boldanov
    • , Patrick Bühr
    • , Rebekka Koller
    • , Vanessa Rueger
    • , Arne Senning
    • , Emanuel Burri
    • , Sophie Buyse
    • , Dahlia-Thao Cao
    • , Fabrizia D’Angelo
    • , Joakim Delarive
    • , Christopher Doerig
    • , Roxane Hessler
    • , Claudia Preissler
    • , Ronald Rentsch
    • , Branislav Risti
    • , Marc Alain Ritz
    • , Michael Steuerwald
    • , Jürg Vögtlin
    • , Markus Sagmeister
    • , Bernhard Sauter
    • , Susanne Schibli
    • , Christiane Sokollik
    • , Johannes Spalinger
    • , Hugo Schlauri
    • , Jean-François Schnegg
    • , Mariam Seirafi
    • , Holger Spangenberger
    • , Philippe Stadler
    • , Peter Staub
    • , Volker Stenz
    • , Michela Tempia-Caliera
    • , Joël Thorens
    • , Kaspar Truninger
    • , Patrick Urfer
    • , Francesco Viani
    • , Dominique Vouillamoz
    • , Silvan Zander
    • , Tina Wyli
    • , L. Jostins
    • , N. A. Kennedy
    • , T. Ahmad
    • , C. A. Lamb
    • , C. Edwards
    • , A. Hart
    • , C. Hawkey
    • , J. C. Mansfield
    • , C. Mowat
    • , W. G. Newman
    • , A. Simmons
    • , M. Tremelling
    • , J. C. Lee
    • , N. J. Prescott
    • , C. G. Mathew
    • , C. W. Lees
    • , D. P. B. McGovern
    • , S. R. Targan
    • , G. Botwin
    • , E. Mengesha
    • , P. Fleshner
    • , C. Landers
    • , D. Li
    • , J. D. Rioux
    • , A. Bitton
    • , J. Côté-Daigneault
    • , M. J. Daly
    • , R. Xavier
    • , K. Morris
    • , G. Boucher
    • , J. H. Cho
    • , C. Abraham
    • , M. Merad
    • , B. Sands
    • , I. Peter
    • , K. Hao
    • , Y. Itan
    • , R. H. Duerr
    • , L. Konnikova
    • , M. B. Schwartz
    • , S. Proksell
    • , E. Johnston
    • , V. Miladinova
    • , W. Chen
    • , S. R. Brant
    • , L. Datta
    • , M. S. Silverberg
    • , L. P. Schumm
    • , S. Birch
    • , M. Giri
    • , K. Gettler
    • , Y. Sharma
    • , C. Stevens
    • , M. Lazarev
    • , T. Haritunians
    • , Scott B. Snapper
    • , Neil Shah
    • , Aleixo M. Muise
    • , David C. Wilson
    • , Holm H. Uhlig
    •  & Carl A. Anderson

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