Genetic variation

Genetic variation describes the genotypic and phenotypic differences between individuals in a population, and between populations. This variation arises through genetic mutation and is important as it provides the diversity within and between populations required for natural selection.

Latest Research and Reviews

  • Reviews |

    Global genomic diversity can provide new opportunities for discovery and translation into therapies, as well as a better understanding of population disease risks. This Review considers the value of examining diverse populations to better understand genetic contributors to disease risk and trait variation.

    • Deepti Gurdasani
    • , Inês Barroso
    • , Eleftheria Zeggini
    •  & Manjinder S. Sandhu
  • Research |

    Genetic analyses of ancestrally diverse populations show evidence of heterogeneity across ancestries and provide insights into clinical implications, highlighting the importance of including ancestrally diverse populations to maximize genetic discovery and reduce health disparities.

    • Genevieve L. Wojcik
    • , Mariaelisa Graff
    • , Katherine K. Nishimura
    • , Ran Tao
    • , Jeffrey Haessler
    • , Christopher R. Gignoux
    • , Heather M. Highland
    • , Yesha M. Patel
    • , Elena P. Sorokin
    • , Christy L. Avery
    • , Gillian M. Belbin
    • , Stephanie A. Bien
    • , Iona Cheng
    • , Sinead Cullina
    • , Chani J. Hodonsky
    • , Yao Hu
    • , Laura M. Huckins
    • , Janina Jeff
    • , Anne E. Justice
    • , Jonathan M. Kocarnik
    • , Unhee Lim
    • , Bridget M. Lin
    • , Yingchang Lu
    • , Sarah C. Nelson
    • , Sung-Shim L. Park
    • , Hannah Poisner
    • , Michael H. Preuss
    • , Melissa A. Richard
    • , Claudia Schurmann
    • , Veronica W. Setiawan
    • , Alexandra Sockell
    • , Karan Vahi
    • , Marie Verbanck
    • , Abhishek Vishnu
    • , Ryan W. Walker
    • , Kristin L. Young
    • , Niha Zubair
    • , Victor Acuña-Alonso
    • , Jose Luis Ambite
    • , Kathleen C. Barnes
    • , Eric Boerwinkle
    • , Erwin P. Bottinger
    • , Carlos D. Bustamante
    • , Christian Caberto
    • , Samuel Canizales-Quinteros
    • , Matthew P. Conomos
    • , Ewa Deelman
    • , Ron Do
    • , Kimberly Doheny
    • , Lindsay Fernández-Rhodes
    • , Myriam Fornage
    • , Benyam Hailu
    • , Gerardo Heiss
    • , Brenna M. Henn
    • , Lucia A. Hindorff
    • , Rebecca D. Jackson
    • , Cecelia A. Laurie
    • , Cathy C. Laurie
    • , Yuqing Li
    • , Dan-Yu Lin
    • , Andres Moreno-Estrada
    • , Girish Nadkarni
    • , Paul J. Norman
    • , Loreall C. Pooler
    • , Alexander P. Reiner
    • , Jane Romm
    • , Chiara Sabatti
    • , Karla Sandoval
    • , Xin Sheng
    • , Eli A. Stahl
    • , Daniel O. Stram
    • , Timothy A. Thornton
    • , Christina L. Wassel
    • , Lynne R. Wilkens
    • , Cheryl A. Winkler
    • , Sachi Yoneyama
    • , Steven Buyske
    • , Christopher A. Haiman
    • , Charles Kooperberg
    • , Loic Le Marchand
    • , Ruth J. F. Loos
    • , Tara C. Matise
    • , Kari E. North
    • , Ulrike Peters
    • , Eimear E. Kenny
    •  & Christopher S. Carlson
    Nature, 1-5
  • Research | | open

    • Shu Tadaka
    • , Fumiki Katsuoka
    • , Masao Ueki
    • , Kaname Kojima
    • , Satoshi Makino
    • , Sakae Saito
    • , Akihito Otsuki
    • , Chinatsu Gocho
    • , Mika Sakurai-Yageta
    • , Inaho Danjoh
    • , Ikuko N. Motoike
    • , Yumi Yamaguchi-Kabata
    • , Matsuyuki Shirota
    • , Seizo Koshiba
    • , Masao Nagasaki
    • , Naoko Minegishi
    • , Atsushi Hozawa
    • , Shinichi Kuriyama
    • , Atsushi Shimizu
    • , Jun Yasuda
    • , Nobuo Fuse
    • , Gen Tamiya
    • , Masayuki Yamamoto
    •  & Kengo Kinoshita

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