Genetic transduction articles from across Nature Portfolio

Systemic Lupus Erythematosus (SLE) is a chronic and progressive autoimmune disease characterized by abnormally activated B cells causing organ damage. Here authors introduce an adoptive cell therapy involving regulatory T cells overexpressing FoxP3 and harboring an anti-CD19 CAR to inhibit pathological B cells and thus tissue-harming autoimmunity in a humanized mouse model.

Oncolytic adenovirus is delivered on T cells and engineered to express a checkpoint inhibitor.

Gene expression in the mouse brain is measured with a simple blood draw.

A study of AAV gene therapy in monkeys proposes that integrated vectors may drive long-term transgene expression.