Genetic linkage study

A genetic linkage study is a family-based method used to map a trait to a genomic location by demonstrating co-segregation of the disease with genetic markers of known chromosomal location; locations identified are more likely to contain a causal genetic variant. This technique is particularly useful for the identification of genes that are inherited in a Mendelian fashion.

Latest Research and Reviews

  • Research | | open

    Simone de Jong et al. examine the balance of common and rare risk for psychiatric disorders in a large family with high incidence of Bipolar Disorder and Major Depressive Disorder. They find that increased polygenic risk over generations could be partially due to assortative mating, which may explain the observation of anticipation in mood disorders.

    • Simone de Jong
    • , Mateus Jose Abdalla Diniz
    • , Andiara Saloma
    • , Ary Gadelha
    • , Marcos L. Santoro
    • , Vanessa K. Ota
    • , Cristiano Noto
    • , Naomi R. Wray
    • , Stephan Ripke
    • , Manuel Mattheisen
    • , Maciej Trzaskowski
    • , Enda M. Byrne
    • , Abdel Abdellaoui
    • , Mark J. Adams
    • , Esben Agerbo
    • , Tracy M. Air
    • , Till F. M. Andlauer
    • , Silviu-Alin Bacanu
    • , Marie Bækvad-Hansen
    • , Aartjan T. F. Beekman
    • , Tim B. Bigdeli
    • , Elisabeth B. Binder
    • , Douglas H. R. Blackwood
    • , Julien Bryois
    • , Henriette N. Buttenschøn
    • , Jonas Bybjerg-Grauholm
    • , Na Cai
    • , Enrique Castelao
    • , Jane Hvarregaard Christensen
    • , Toni-Kim Clarke
    • , Jonathan R. I. Coleman
    • , Lucía Colodro-Conde
    • , Baptiste Couvy-Duchesne
    • , Nick Craddock
    • , Gregory E. Crawford
    • , Gail Davies
    • , Ian J. Deary
    • , Franziska Degenhardt
    • , Eske M. Derks
    • , Nese Direk
    • , Conor V. Dolan
    • , Erin C. Dunn
    • , Thalia C. Eley
    • , Valentina Escott-Price
    • , Farnush Farhadi Hassan Kiadeh
    • , Hilary K. Finucane
    • , Andreas J. Forstner
    • , Josef Frank
    • , Héléna A. Gaspar
    • , Michael Gill
    • , Fernando S. Goes
    • , Scott D. Gordon
    • , Jakob Grove
    • , Christine Søholm Hansen
    • , Thomas F. Hansen
    • , Stefan Herms
    • , Ian B. Hickie
    • , Per Hoffmann
    • , Georg Homuth
    • , Carsten Horn
    • , Jouke-Jan Hottenga
    • , David M. Hougaard
    • , Marcus Ising
    • , Rick Jansen
    • , Ian Jones
    • , Lisa A Jones
    • , Eric Jorgenson
    • , James A. Knowles
    • , Isaac S. Kohane
    • , Julia Kraft
    • , Warren W. Kretzschmar
    • , Jesper Krogh
    • , Zoltán Kutalik
    • , Yihan Li
    • , Penelope A. Lind
    • , Donald J. MacIntyre
    • , Dean F. MacKinnon
    • , Robert M. Maier
    • , Wolfgang Maier
    • , Jonathan Marchini
    • , Hamdi Mbarek
    • , Patrick McGrath
    • , Peter McGuffin
    • , Sarah E. Medland
    • , Divya Mehta
    • , Christel M. Middeldorp
    • , Evelin Mihailov
    • , Yuri Milaneschi
    • , Lili Milani
    • , Francis M. Mondimore
    • , Grant W. Montgomery
    • , Sara Mostafavi
    • , Niamh Mullins
    • , Matthias Nauck
    • , Bernard Ng
    • , Michel G. Nivard
    • , Dale R. Nyholt
    • , Hogni Oskarsson
    • , Michael J. Owen
    • , Jodie N. Painter
    • , Carsten Bøcker Pedersen
    • , Marianne Giørtz Pedersen
    • , Roseann E. Peterson
    • , Erik Pettersson
    • , Wouter J. Peyrot
    • , Giorgio Pistis
    • , Danielle Posthuma
    • , Jorge A. Quiroz
    • , Per Qvist
    • , John P. Rice
    • , Brien P. Riley
    • , Margarita Rivera
    • , Saira Saeed Mirza
    • , Robert Schoevers
    • , Eva C. Schulte
    • , Ling Shen
    • , Stanley I. Shyn
    • , Engilbert Sigurdsson
    • , Grant C. B. Sinnamon
    • , Johannes H. Smit
    • , Daniel J. Smith
    • , Hreinn Stefansson
    • , Stacy Steinberg
    • , Fabian Streit
    • , Jana Strohmaier
    • , Katherine E. Tansey
    • , Henning Teismann
    • , Alexander Teumer
    • , Wesley Thompson
    • , Pippa A. Thomson
    • , Thorgeir E. Thorgeirsson
    • , Matthew Traylor
    • , Jens Treutlein
    • , Vassily Trubetskoy
    • , André G. Uitterlinden
    • , Daniel Umbricht
    • , Sandra Van der Auwera
    • , Albert M. van Hemert
    • , Alexander Viktorin
    • , Peter M. Visscher
    • , Yunpeng Wang
    • , Bradley T. Webb
    • , Shantel Marie Weinsheimer
    • , Jürgen Wellmann
    • , Gonneke Willemsen
    • , Stephanie H. Witt
    • , Yang Wu
    • , Hualin S. Xi
    • , Jian Yang
    • , Futao Zhang
    • , Volker Arolt
    • , Bernhard T. Baune
    • , Klaus Berger
    • , Dorret I. Boomsma
    • , Sven Cichon
    • , Udo Dannlowski
    • , E. J. C. de Geus
    • , J. Raymond DePaulo
    • , Enrico Domenici
    • , Katharina Domschke
    • , Tõnu Esko
    • , Hans J. Grabe
    • , Steven P. Hamilton
    • , Caroline Hayward
    • , Andrew C. Heath
    • , Kenneth S. Kendler
    • , Stefan Kloiber
    • , Glyn Lewis
    • , Qingqin S. Li
    • , Susanne Lucae
    • , Pamela A. F. Madden
    • , Patrik K. Magnusson
    • , Nicholas G. Martin
    • , Andrew M. McIntosh
    • , Andres Metspalu
    • , Ole Mors
    • , Preben Bo Mortensen
    • , Bertram Müller-Myhsok
    • , Merete Nordentoft
    • , Markus M. Nöthen
    • , Michael C. O’Donovan
    • , Sara A. Paciga
    • , Nancy L. Pedersen
    • , Brenda W. J. H. Penninx
    • , Roy H. Perlis
    • , David J. Porteous
    • , James B. Potash
    • , Martin Preisig
    • , Marcella Rietschel
    • , Catherine Schaefer
    • , Thomas G. Schulze
    • , Jordan W. Smoller
    • , Kari Stefansson
    • , Henning Tiemeier
    • , Rudolf Uher
    • , Henry Völzke
    • , Myrna M. Weissman
    • , Thomas Werge
    • , Cathryn M. Lewis
    • , Douglas F. Levinson
    • , Anders D. Børglum
    • , Patrick F. Sullivan
    • , Sandra Meier
    • , John Strauss
    • , Wei Xu
    • , John B. Vincent
    • , Keith Matthews
    • , Manuel Ferreira
    • , Colm O’Dushlaine
    • , Shaun Purcell
    • , Soumya Raychaudhuri
    • , Douglas M. Ruderfer
    • , Pamela Sklar
    • , Laura J. Scott
    • , Matthew Flickinger
    • , Margit Burmeister
    • , Jun Li
    • , Weihua Guan
    • , Devin Absher
    • , Robert C. Thompson
    • , Fan Guo Meng
    • , Alan F. Schatzberg
    • , William E. Bunney
    • , Jack D. Barchas
    • , Stanley J. Watson
    • , Richard M. Myers
    • , Huda Akil
    • , Michael Boehnke
    • , Kimberly Chambert
    • , Jennifer Moran
    • , Edward Scolnick
    • , Srdjan Djurovic
    • , Ingrid Melle
    • , Gunnar Morken
    • , Aiden Corvin
    • , Adebayo Anjorin
    • , Radhika Kandaswamy
    • , Jacob Lawrence
    • , Alan W. McLean
    • , Benjamin S. Pickard
    • , Sarah E. Bergen
    • , Vishwajit Nimgaonkar
    • , Mikael Landén
    • , Martin Schalling
    • , Urban Osby
    • , Lena Backlund
    • , Louise Frisén
    • , Niklas Langstrom
    • , Eli Stahl
    • , Amanda Dobbyn
    • , Stéphane Jamain
    • , Bruno Etain
    • , Frank Bellivier
    • , Markus Leber
    • , Anna Maaser
    • , Sascha B. Fischer
    • , Céline S. Reinbold
    • , Sarah Kittel-Schneider
    • , Janice M. Fullerton
    • , Lilijana Oruč
    • , José G. Para
    • , Fermin Mayoral
    • , Fabio Rivas
    • , Piotr M. Czerski
    • , Jutta Kammerer-Ciernioch
    • , Helmut Vedder
    • , Margitta Borrmann-Hassenbach
    • , Andrea Pfennig
    • , Paul Brennan
    • , James D. McKay
    • , Manolis Kogevinas
    • , Markus Schwarz
    • , Peter R. Schofield
    • , Thomas W. Mühleisen
    • , Johannes Schumacher
    • , Michael Bauer
    • , Adam Wright
    • , Philip B. Mitchell
    • , Martin Hautzinger
    • , John R. Kelsoe
    • , Tiffany A. Greenwood
    • , Caroline M. Nievergelt
    • , Paul D. Shilling
    • , Erin N. Smith
    • , Cinnamon S. Bloss
    • , Howard J. Edenberg
    • , Daniel L. Koller
    • , Elliot S. Gershon
    • , Chunyu Liu
    • , Judith A. Badner
    • , William A. Scheftner
    • , William B. Lawson
    • , Evaristus A. Nwulia
    • , Maria Hipolito
    • , William Coryell
    • , John Rice
    • , William Byerley
    • , Francis J. McMahon
    • , Falk W. Lohoff
    • , Peter P. Zandi
    • , Pamela B. Mahon
    • , Melvin G. McInnis
    • , Sebastian Zöllner
    • , Peng Zhang
    • , Szabolcs Szelinger
    • , David St. Clair
    • , Sian Caesar
    • , Katherine Gordon-Smith
    • , Christine Fraser
    • , Elaine K. Green
    • , Detelina Grozeva
    • , Marian L. Hamshere
    • , George Kirov
    • , Ivan Nikolov
    • , David A. Collier
    • , Amanda Elkin
    • , Richard Williamson
    • , Allan H. Young
    • , I. Nicol Ferrier
    • , Vihra Milanova
    • , Martin Alda
    • , Pablo Cervantes
    • , Cristiana Cruceanu
    • , Guy A. Rouleau
    • , Gustavo Turecki
    • , Sara Paciga
    • , Ashley R. Winslow
    • , Maria Grigoroiu-Serbanescu
    • , Roel Ophoff
    • , Rolf Adolfsson
    • , Annelie Nordin Adolfsson
    • , Jurgen Del-Favero
    • , Carlos Pato
    • , Joanna M. Biernacka
    • , Mark A. Frye
    • , Derek Morris
    • , Nicholas J. Schork
    • , Andreas Reif
    • , Jolanta Lissowska
    • , Joanna Hauser
    • , Neonila Szeszenia-Dabrowska
    • , Kevin McGhee
    • , Emma Quinn
    • , Valentina Moskvina
    • , Peter A. Holmans
    • , Anne Farmer
    • , James L. Kennedy
    • , Ole A. Andreassen
    • , Morten Mattingsdal
    • , Michael Gill
    • , Nicholas J. Bass
    • , Hugh Gurling
    • , Andrew McQuillin
    • , René Breuer
    • , Christina Hultman
    • , Paul Lichtenstein
    • , Laura M. Huckins
    • , Marion Leboyer
    • , Mark Lathrop
    • , John Nurnberger
    • , Michael Steffens
    • , Tatiana M. Foroud
    • , Wade H. Berrettini
    • , David W. Craig
    • , Jianxin Shi
    • , Charles Curtis
    • , Stephen J. Newhouse
    • , Hamel Patel
    • , Lynsey S. Hall
    • , Paul F. O`Reilly
    • , Sintia I. Belangero
    • , Rodrigo A. Bressan
    •  & Gerome Breen
  • Research |

    • Heming Wang
    • , Priyanka Nandakumar
    • , Fasil Tekola-Ayele
    • , Bamidele O. Tayo
    • , Erin B. Ware
    • , C. Charles Gu
    • , Yingchang Lu
    • , Jie Yao
    • , Wei Zhao
    • , Jennifer A. Smith
    • , Jacklyn N. Hellwege
    • , Xiuqing Guo
    • , Todd L. Edwards
    • , Ruth J. F. Loos
    • , Donna K. Arnett
    • , Myriam Fornage
    • , Charles Rotimi
    • , Sharon L. R. Kardia
    • , Richard S. Cooper
    • , D. C. Rao
    • , Georg Ehret
    • , Aravinda Chakravarti
    •  & Xiaofeng Zhu

News and Comment