Genetic interaction

Genetic interaction is the phenomenon where the effects of one gene are modified by one or several other genes.

Latest Research and Reviews

  • Research | | open

    Alfred Pozarickij et al. present an analysis of effect-size heterogeneity among myopia-associated variants in the UK Biobank dataset. They find evidence for non-uniform effects for 45% of variants using a conservative cutoff, suggesting that gene-environment and/or gene-gene interactions are pervasive in myopia.

    • Alfred Pozarickij
    • , Cathy Williams
    • , Pirro G. Hysi
    • , Jeremy A. Guggenheim
    • , Tariq Aslam
    • , Sarah A. Barman
    • , Jenny H. Barrett
    • , Paul Bishop
    • , Peter Blows
    • , Catey Bunce
    • , Roxana O. Carare
    • , Usha Chakravarthy
    • , Michelle Chan
    • , Sharon Y.L. Chua
    • , David P. Crabb
    • , Philippa M. Cumberland
    • , Alexander Day
    • , Parul Desai
    • , Bal Dhillon
    • , Andrew D. Dick
    • , Cathy Egan
    • , Sarah Ennis
    • , Paul Foster
    • , Marcus Fruttiger
    • , John E.J. Gallacher
    • , David F. Garway-Heath
    • , Jane Gibson
    • , Dan Gore
    • , Chris J. Hammond
    • , Alison Hardcastle
    • , Simon P. Harding
    • , Ruth E. Hogg
    • , Pearse A. Keane
    • , Sir Peng T. Khaw
    • , Anthony P. Khawaja
    • , Gerassimos Lascaratos
    • , Andrew J. Lotery
    • , Tom Mac Gillivray
    • , Sarah Mackie
    • , Keith Martin
    • , Michelle McGaughey
    • , Bernadette McGuinness
    • , Gareth J. McKay
    • , Martin McKibbin
    • , Danny Mitry
    • , Tony Moore
    • , James E. Morgan
    • , Zaynah A. Muthy
    • , Eoin O’Sullivan
    • , Chris G. Owen
    • , Praveen Patel
    • , Euan Paterson
    • , Tunde Peto
    • , Axel Petzold
    • , Jugnoo S. Rahi
    • , Alicja R. Rudnikca
    • , Jay Self
    • , Sobha Sivaprasad
    • , David Steel
    • , Irene Stratton
    • , Nicholas Strouthidis
    • , Cathie Sudlow
    • , Dhanes Thomas
    • , Emanuele Trucco
    • , Adnan Tufail
    • , Veronique Vitart
    • , Stephen A. Vernon
    • , Ananth C. Viswanathan
    • , Katie Williams
    • , Jayne V. Woodside
    • , Max M. Yates
    • , Jennifer Yip
    •  & Yalin Zheng
  • Research |

    Massively parallel Cpf1 array profiling (MCAP) targets genes and gene pairs that are candidate drivers of metastasis in cancer. In vivo profiling of single and double gene knockouts enables quantitative mapping of the genes’ contribution to metastatic phenotypes.

    • Ryan D. Chow
    • , Guangchuan Wang
    • , Lupeng Ye
    • , Adan Codina
    • , Hyunu Ray Kim
    • , Li Shen
    • , Matthew B. Dong
    • , Youssef Errami
    •  & Sidi Chen
    Nature Methods 16, 405-408
  • Research |

    mRNA that contains a premature termination codon (PTC) triggers a genetic compensation response that involves both transcription of its homologous genes and degradation of the mutated transcript by the nonsense-mediated decay pathway.

    • Zhipeng Ma
    • , Peipei Zhu
    • , Hui Shi
    • , Liwei Guo
    • , Qinghe Zhang
    • , Yanan Chen
    • , Shuming Chen
    • , Zhe Zhang
    • , Jinrong Peng
    •  & Jun Chen
    Nature 568, 259-263
  • Research | | open

    An essential gene may become non-essential when another gene is mutated. Here, the authors investigate this type of digenic interaction, termed ‘bypass of essentiality’, in the fission yeast Schizosaccharomyces pombe, and show that bypassable essential genes are common and share certain features.

    • Jun Li
    • , Hai-Tao Wang
    • , Wei-Tao Wang
    • , Xiao-Ran Zhang
    • , Fang Suo
    • , Jing-Yi Ren
    • , Ying Bi
    • , Ying-Xi Xue
    • , Wen Hu
    • , Meng-Qiu Dong
    •  & Li-Lin Du

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