Gammadelta T cells

Gammadelta T cells (γδ T cells) are T cells that express a unique T-cell receptor (TCR) composed of one γ-chain and one δ-chain. Gammadelta T cells are of low abundance in the body, are found in the gut mucosa, skin, lungs and uterus, and are involved in the initiation and propagation of immune responses.

Latest Research and Reviews

News and Comment

  • News and Views |

    In response to epithelial DNA damage, tissue-resident γδ T cells initiate and shape a tumor-protective IgE response that requires CD4+ T cells and immune effector cells expressing the high-affinity IgE receptor FcεRI.

    • J. Michael McGraw
    •  & Wendy L. Havran
    Nature Immunology 19, 793-795
  • Research Highlights |

    Tumour-associated neutrophils can inhibit the proliferation of pro-tumoural interleukin-17 (IL-17)+ γδ T cells via production of reactive oxygen species.

    • Anna Dart
    Nature Reviews Cancer 18, 466-467
  • News and Views |

    γδ T cells accumulate with age in adipose tissue and produce the cytokine IL-17, which controls the homeostasis of regulatory T cells and adaptive thermogenesis. Thus, maintenance of core body temperature unexpectedly relies on these adipose tissue–resident γδ17 T cells.

    • Pedro H. Papotto
    •  & Bruno Silva-Santos
    Nature Immunology 19, 427-429