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The fungal host response is the process by which the host interacts with and responds to fungi that colonize or infect it. This includes defense mechanisms such as the immune response.
This work reveals a mechanism of cGAS- and STING-dependent type I IFN induction in response to biofilm-associated Candida albicans DNA packaged in extracellular vesicles.
Receptor dimerization can modulate immune responses during various microbial infections. Here, the authors show that C-type lectin receptor-2d (CLEC2D) negatively regulates antifungal immunity through forming homodimers or heterodimers with TLR2.
The study explores immune evasion mechanisms of T. marneffei infection, highlighting the role of alternative splicing (AS). T. marneffei triggers the upregulation of NCOR2-013, inhibiting pro-inflammatory cytokine production via histone acetylation. TUT1 regulates NCOR2-013, contributing to immune evasion. This sheds light on T. marneffei’s immune evasion at the molecular level, offering potential talaromycosis therapy targets.
This study shows that gut fungi, in particular Candida albicans, induce the production of systemic antifungal antibodies, which can provide protection against systemic fungal infections.
This study provides insights into how a mycovirus decreases the pathogenicity of its fungal host and promotes plant defences, and how this can be translated into the development of a plant vaccine.