Follicular B cells

Follicular B cells populate the B cell follicles of the spleen and lymph nodes, associating with follicular dendritic cells. They have a mature B cell phenotype that is distinct from other B cell populations, recirculate in the blood and require cognate help from T cells to become antibody-producing memory B cells.

Latest Research and Reviews

  • Research | | open

    Microbiota impacts all major aspects of physiology, but little is known about its effects on age-related changes in immune responses. Here the authors show that gut microbiota transfer between adult and old mice increases local but not systemic germinal centre responses regardless of age directionality.

    • Marisa Stebegg
    • , Alyssa Silva-Cayetano
    • , Silvia Innocentin
    • , Timothy P. Jenkins
    • , Cinzia Cantacessi
    • , Colin Gilbert
    •  & Michelle A. Linterman
  • Research |

    Human follicular lymphomas arise from germinal center B cells. Milpied and colleagues use single-cell transcriptomic analysis to show that follicular lymphoma cells lose synchronized gene-expression patterns that characterize normal germinal center B cells.

    • Pierre Milpied
    • , Iñaki Cervera-Marzal
    • , Marie-Laure Mollichella
    • , Bruno Tesson
    • , Gabriel Brisou
    • , Alexandra Traverse-Glehen
    • , Gilles Salles
    • , Lionel Spinelli
    •  & Bertrand Nadel
    Nature Immunology 19, 1013-1024
  • Research | | open

    Germinal center (GC) is where B cells interact with other immune cells for optimal induction of antibody responses. Here the authors show that galectin-3 regulates GC development by modulating interferon-γ and B cell-intrinsic signaling, such that galectin-3 deficiency mice exhibit lupus-like autoimmune symptoms.

    • Cristian Gabriel Beccaria
    • , María Carolina Amezcua Vesely
    • , Facundo Fiocca Vernengo
    • , Ricardo Carlos Gehrau
    • , María Cecilia Ramello
    • , Jimena Tosello Boari
    • , Melisa Gorosito Serrán
    • , Juan Mucci
    • , Eliane Piaggio
    • , Oscar Campetella
    • , Eva Virginia Acosta Rodríguez
    • , Carolina Lucía Montes
    •  & Adriana Gruppi
  • Research | | open

    B-cell encounter with antigen is thought to result in anergy, cell death, or a productive B-cell response. Here the authors show that transient antigen acquisition can enable B-cell recruitment into productive responses or a return to a naive-like state, depending on availability of T-cell help.

    • Jackson S. Turner
    • , Matangi Marthi
    • , Zachary L. Benet
    •  & Irina Grigorova
  • Research |

    Splenic marginal zone B cells suppress atherosclerosis in mice by dampening the proatherogenic T follicular helper response via a PDL1-dependent interaction with T follicular helper cells.

    • Meritxell Nus
    • , Andrew P Sage
    • , Yuning Lu
    • , Leanne Masters
    • , Brian Y H Lam
    • , Stephen Newland
    • , Sandra Weller
    • , Dimitrios Tsiantoulas
    • , Juliette Raffort
    • , Damiënne Marcus
    • , Alison Finigan
    • , Lauren Kitt
    • , Nichola Figg
    • , Reinhold Schirmbeck
    • , Manfred Kneilling
    • , Giles S H Yeo
    • , Christoph J Binder
    • , José Luis de la Pompa
    •  & Ziad Mallat
    Nature Medicine 23, 601-610

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