Fluorescent probes

Definition

Fluorescent probes are molecules that absorb light of a specific wavelength and emit light of a different, typically longer, wavelength (a process known as fluorescence), and are used to study biological samples. The molecules, also known as fluorophores, can be attached to a target molecule and act as a marker for analysis with fluorescence microscopy.

Latest Research and Reviews

News and Comment

  • News and Views |

    For decades chemists have focused on increasing the brightness of fluorophores. In super-resolution microscopy, however, fluorophores that preferentially exist in a non-fluorescent state, but occasionally re-arrange into a fluorescent form, can give better results.

    • Gražvydas Lukinavičius
    •  & Kai Johnsson
    Nature Chemistry 6, 663–664
  • News and Views |

    Tuning the luminescence lifetimes of upconversion nanocrystals through lanthanide doping provides new opportunities for optical multiplexing in the time domain for applications in imaging and security marking.

    • Renren Deng
    •  & Xiaogang Liu
    Nature Photonics 8, 10–12