Filopodia articles from across Nature Portfolio

It is now shown that cells migrate robustly on soft, viscoelastic substrates with fast stress relaxation using a migration mode marked by a rounded cell morphology and filopodia protrusions extending at the leading edge.

Keratinocytes are organised into a periodic pattern in feather branching, but how this is regulated is unclear. Here, the authors show that there is a coordinated change in cell shape and adherence, mediated by Notch, FGF signalling and Rho GTPases, which in turn regulates feather branching.

The lack of an appropriate method has hampered quantitative measurements of cell chirality. Here, the authors combine Riesz transform-differential interference contrast microscopy and computational kinematic analysis to reveal chiral cell motility of neuronal growth cone filopodia and cellular slime mold.

A new study reveals an involvement of SLC22A3 in the development of familial oesophageal squamous cell carcinoma (ESCC). Reduced expression of SLC22A3 is detected not only in ESCC tumours but also in non-tumour tissues of patients with familial ESCC. Interestingly, adenosine-to-inosine editing of SLC22A3 mRNA is proposed to drive early tumour invasion and metastasis, by inhibiting SLC22A3 expression.

Anin vitrosystem shows that filopodia can self-assemble.