Exocytosis

Exocytosis is the process by which cytoplasmic secretory vesicles fuse with the cellular membrane, releasing contents to the extracellular space.

Latest Research and Reviews

News and Comment

  • News and Views |

    It is now clear that key autophagy proteins possess alternative functions, distinct from their conventional roles in autophagy. Adding to this emerging field, a new study shows how ATG16L1 acts to promote plasma membrane repair following damage by pore-forming bacteria.

    • Oliver Florey
    Nature Microbiology 3, 1334-1335
  • News and Views |

    Inflammation and reactive oxygen species (ROS) production after central nervous system injury are thought to enhance tissue damage and hamper neuronal regeneration. Evidence now suggests that NADPH2 oxidase delivery from macrophages to injured neurons through extracellular vesicles, promotes ROS signalling and axon recovery.

    • Eva-Maria Krämer-Albers
    Nature Cell Biology 20, 225-226
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  • News and Views |

    An actin filament coat promotes cargo expulsion from large exocytosing vesicles, but the mechanisms of coat formation and force generation have been poorly characterized. Elegant imaging studies of the Drosophila melanogaster salivary gland now reveal how actin and myosin are recruited, and show that myosin II forms a contractile 'cage' that facilitates exocytosis.

    • Christien J. Merrifield
    Nature Cell Biology 18, 142-144