Erythropoiesis is the process by which red blood cells (erythrocytes) are produced. During human foetal development, erythropoiesis first occurs in the yolk sac, then in the foetal liver and then, in the third trimester and after birth, in the bone marrow.

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  • News and Views |

    CCCTC-binding factor (CTCF) sites are enriched at the boundaries of topologically associated domains (TADs), but their function within TADs is unclear. Removal of sub-TAD CTCF sites adjacent to the α-globin enhancers is now shown to result in inappropriate activation of neighbouring genes. Intra-TAD enhancer insulation might be broadly important for tissue specificity of enhancers.

    • Ivan Krivega
    •  & Ann Dean
    Nature Cell Biology 19, 883–885
  • News and Views |

    Lineage bias among early hematopoietic progenitor cells is specified by transcription-factor programming, and lineage switching reduces the quantity of cells produced.

    • Alberto Yáñez
    • , Helen S Goodridge
    •  & H Leighton Grimes
    Nature Immunology 18, 872–873
  • News and Views |

    Two complementary approaches for directing human hematopoietic stem cells along the T cell lineage will have applications in both fundamental and translational research.

    • Anne-Catherine Dolens
    •  & Tom Taghon
    Nature Methods 14, 477–478
  • News and Views |

    Determining the differentiation potential of stem and progenitor cells is essential for understanding their function, yet our ability to do so is limited by the restrictions of experimental assays. Based on single-cell functional and molecular profiling experiments, a new computational approach shows how lineage commitment may occur in human haematopoiesis.

    • Fiona K. Hamey
    •  & Berthold Göttgens
    Nature Cell Biology 19, 261–263