ER-associated degradation

Definition

ER-associated degradation (ERAD) is the process by which the endoplasmic reticulum (ER) directs the degradation of misfolded or inappropriate proteins. The steps of ERAD include recognition of a misfolded protein – for instance for its inappropriate exposure of glycan residues – retro-translocation of the protein into the cytosol, and ubiquitin-dependent degradation by the proteasome.

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