Featured
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| Open AccessDetection of DNA methylation signatures through the lens of genomic imprinting
- Jean-Noël Hubert
- , Nathalie Iannuccelli
- & Julie Demars
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Article
| Open AccessA CIC-related-epigenetic factors-based model associated with prediction, the tumor microenvironment and drug sensitivity in osteosarcoma
- Bin Yu
- , Chengkui Geng
- & Zhuoyuan Chen
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Article
| Open AccessGenetic evidence for causal effects of leukocyte counts on risk for rheumatoid arthritis
- Jin-Mei You
- , Yao-Chen Zhang
- & Sheng-Xiao Zhang
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| Open AccessCRISPR-broad: combined design of multi-targeting gRNAs and broad, multiplex target finding
- Alaguraj Veluchamy
- , Kaian Teles
- & Wolfgang Fischle
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| Open AccessDNA hypomethylation characterizes genes encoding tissue-dominant functional proteins in liver and skeletal muscle
- Hideki Maehara
- , Toshiya Kokaji
- & Shinya Kuroda
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| Open AccessGenome-wide epigenetic modifications in sports horses during training as an adaptation phenomenon
- Katia Cappelli
- , Samanta Mecocci
- & Stefano Capomaccio
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Article
| Open AccessDiet-induced rewiring of the Wnt gene regulatory network connects aberrant splicing to fatty liver and liver cancer in DIAMOND mice
- Ana López-Pérez
- , Silvia Remeseiro
- & Andreas Hörnblad
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Article
| Open AccessMulti-ancestry epigenome-wide analyses identify methylated sites associated with aortic augmentation index in TOPMed MESA
- Xiaowei Hu
- , Jeongok G. Logan
- & Ani Manichaikul
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Article
| Open AccessAllele specific binding of histone modifications and a transcription factor does not predict allele specific expression in correlated ChIP-seq peak-exon pairs
- Claire P. Prowse-Wilkins
- , Jianghui Wang
- & Amanda J. Chamberlain
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Article
| Open AccessGenome-wide DNA methylation patterns in bumble bee (Bombus vosnesenskii) populations from spatial-environmental range extremes
- Sarthok Rasique Rahman
- & Jeffrey D. Lozier
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Article
| Open AccessDifferential exon usage of developmental genes is associated with deregulated epigenetic marks
- Hoang Thu Trang Do
- , Siba Shanak
- & Volkhard Helms
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Article
| Open AccessEstablishing the contribution of active histone methylation marks to the aging transcriptional landscape of Drosophila photoreceptors
- Juan Jauregui-Lozano
- , Sarah E. McGovern
- & Vikki M. Weake
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Article
| Open AccessIntergenerational impact of dietary protein restriction in dairy ewes on epigenetic marks in the perirenal fat of their suckling lambs
- Pablo A. S. Fonseca
- , Aroa Suárez-Vega
- & Juan-José Arranz
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Article
| Open AccessMajor cell-types in multiomic single-nucleus datasets impact statistical modeling of links between regulatory sequences and target genes
- Francis J. A. Leblanc
- & Guillaume Lettre
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Article
| Open AccessRe-analysis of publicly available methylomes using signal detection yields new information
- Alenka Hafner
- & Sally Mackenzie
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| Open AccessMaternal diet induces persistent DNA methylation changes in the muscle of beef calves
- Rocío Amorín
- , Lihe Liu
- & Francisco Peñagaricano
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Article
| Open AccessscATAC-Seq reveals heterogeneity associated with spermatogonial differentiation in cultured male germline stem cells
- Hoi Ching Suen
- , Alfred Chun Shui Luk
- & Jinyue Liao
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Editorial
| Open AccessGenome editing
Recent advances in genome editing technologies have redefined our ability to probe and precisely edit the human genome and epigenome in vitro and in vivo. More specifically, RNA-guided CRISPR/Cas systems have revolutionized the field due to their simplicity in design and adaptability across biological systems. This Collection highlights results in CRISPR/Cas technology that increase the efficiency of precision genome editing, and allow genetic manipulation in model systems traditionally intractable to site-directed gene modification.
- Maura McGrail
- , Tetsushi Sakuma
- & Leonidas Bleris
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Article
| Open AccessLong term environmental variability modulates the epigenetics of maternal traits of kelp crabs in the coast of Chile
- Simone Baldanzi
- , Gonzalo S. Saldías
- & Francesca Porri
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Article
| Open AccessMeta-analysis of epigenome-wide association studies of major depressive disorder
- Qingqin S. Li
- , Randall L. Morrison
- & Wayne C. Drevets
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Article
| Open AccessA multi-omics longitudinal study of the murine retinal response to chronic low-dose irradiation and simulated microgravity
- Prachi Kothiyal
- , Greg Eley
- & Parastou Eslami
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Article
| Open AccessHydroxymethylation profile of cell-free DNA is a biomarker for early colorectal cancer
- Nicolas J. Walker
- , Mamunur Rashid
- & Joanna D. Holbrook
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| Open AccessPre-diagnostic DNA methylation in blood leucocytes in cutaneous melanoma; a nested case–control study within the Norwegian Women and Cancer cohort
- Christian M. Page
- , Therese H. Nøst
- & Marit B. Veierød
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Article
| Open AccessThymocyte regulatory variant alters transcription factor binding and protects from type 1 diabetes in infants
- Niina Sandholm
- , Arcadio Rubio García
- & John A. Todd
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Article
| Open AccessmiRNA expression patterns in blood leukocytes and milk somatic cells of goats infected with small ruminant lentivirus (SRLV)
- Daria M. Urbańska
- , Justyna Jarczak
- & Emilia Bagnicka
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Article
| Open AccessGenome-wide profiling of histone H3K4me3 and H3K27me3 modifications in individual blastocysts by CUT&Tag without a solid support (NON-TiE-UP CUT&Tag)
- Kazuki Susami
- , Shuntaro Ikeda
- & Naojiro Minami
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Article
| Open AccessSuper-resolution visualization of chromatin loop folding in human lymphoblastoid cells using interferometric photoactivated localization microscopy
- Zofia Parteka-Tojek
- , Jacqueline Jufen Zhu
- & Yijun Ruan
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Article
| Open AccessCirculating microRNA profiling is altered in the acute respiratory distress syndrome related to SARS-CoV-2 infection
- Natalia Garcia-Giralt
- , Juan Du
- & Robert Güerri-Fernández
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Article
| Open AccessFeedlot diets containing different starch levels and additives change the cecal proteome involved in cattle’s energy metabolism and inflammatory response
- Leone Campos Rocha
- , Andrey Sávio de Almeida Assunção
- & Pedro de Magalhães Padilha
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Article
| Open AccessDNA methylation in peripheral tissues and left-handedness
- Veronika V. Odintsova
- , Matthew Suderman
- & Jenny van Dongen
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Article
| Open AccessLoops, topologically associating domains, compartments, and territories are elastic and robust to dramatic nuclear volume swelling
- Jacob T. Sanders
- , Rosela Golloshi
- & Rachel Patton McCord
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Article
| Open AccessDifferent expression of circulating microRNA profile and plasma SP-D in Tibetan COPD patients
- Xue-feng Shi
- , Xiang He
- & Jie Duo
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Article
| Open AccessPrognostic signature based on m6A-related lncRNAs to predict overall survival in pancreatic ductal adenocarcinoma
- Qiong Wu
- , Lei Chen
- & Zhigang Zhu
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Article
| Open AccessIntegrative epigenomics in Sjögren´s syndrome reveals novel pathways and a strong interaction between the HLA, autoantibodies and the interferon signature
- María Teruel
- , Guillermo Barturen
- & Marta E. Alarcón-Riquelme
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Article
| Open AccessMapping cis-regulatory elements in the midgestation mouse placenta
- Rebekah R. Starks
- , Haninder Kaur
- & Geetu Tuteja
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Article
| Open AccessEstimating DNA methylation potential energy landscapes from nanopore sequencing data
- Jordi Abante
- , Sandeep Kambhampati
- & John Goutsias
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Article
| Open AccessNanopore sequencing and de novo assembly of a misidentified Camelpox vaccine reveals putative epigenetic modifications and alternate protein signal peptides
- Zack Saud
- , Matthew D. Hitchings
- & Tariq M. Butt
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Article
| Open AccessTranscriptional overlap links DNA hypomethylation with DNA hypermethylation at adjacent promoters in cancer
- Jean S. Fain
- , Axelle Loriot
- & Charles De Smet
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Article
| Open AccessInvestigating crosstalk between H3K27 acetylation and H3K4 trimethylation in CRISPR/dCas-based epigenome editing and gene activation
- Weiye Zhao
- , Ying Xu
- & Fu-Sen Liang
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Article
| Open AccessThe role of epigenetic modifications, long-range contacts, enhancers and topologically associating domains in the regulation of glioma grade-specific genes
- Ilona E. Grabowicz
- , Bartek Wilczyński
- & Michał J. Dąbrowski
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Article
| Open AccessSMARCB1 deletion in atypical teratoid rhabdoid tumors results in human endogenous retrovirus K (HML-2) expression
- Tara T. Doucet-O’Hare
- , Brianna L. DiSanza
- & Avindra Nath
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Article
| Open AccessHeat stress and immune response phenotype affect DNA methylation in blood mononuclear cells from Holstein dairy cows
- A. M. Livernois
- , B. A. Mallard
- & A. Cánovas
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Article
| Open AccessComparative analysis of histone H3K4me3 modifications between blastocysts and somatic tissues in cattle
- Mao Ishibashi
- , Shuntaro Ikeda
- & Naojiro Minami
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Article
| Open AccessLow biological fluctuation of mitochondrial CpG and non-CpG methylation at the single-molecule level
- Chloe Goldsmith
- , Jesús Rafael Rodríguez-Aguilera
- & Hector Hernandez-Vargas
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Article
| Open AccessMethylation analysis of Klebsiella pneumoniae from Portuguese hospitals
- Anton Spadar
- , João Perdigão
- & Taane G. Clark
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Article
| Open AccessGenome-wide methylome analysis of two strains belonging to the hypervirulent Neisseria meningitidis serogroup W ST-11 clonal complex
- Bianca Stenmark
- , Lorraine Eriksson
- & Paula Mölling
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Article
| Open AccessStructural insights of human N-acetyltransferase 10 and identification of its potential novel inhibitors
- Mahmood Hassan Dalhat
- , Hisham N. Altayb
- & Hani Choudhry
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Article
| Open AccessCD4+ T cells from children with active juvenile idiopathic arthritis show altered chromatin features associated with transcriptional abnormalities
- Evan Tarbell
- , Kaiyu Jiang
- & James N. Jarvis