Epigenetics in the nervous system articles from across Nature Portfolio

Calcitonin gene-related peptide (CGRP) causes anxiety by modulating the HP1γKLF11-MAOB pathway, depleting dopamine in the dorsal hippocampus, and increasing MAOB while reducing dopamine levels, leading to anxiety-like behaviors.

Maternal high fat diet during lactation predisposes offspring to develop obesity in males more than females. Here, authors show expansion of key metabolic related hypothalamic neuron populations in male but not female mice, in response to maternal fat intake.

A new study shows that brain-resident parenchymal border macrophages (PBMs) maintain perivascular extracellular matrix composition by the release of matrix metalloproteinases. Depletion of PBMs suppressed glymphatic fluid transport, underscoring their responsibility for perivascular space homeostasis and brain protein clearance.

Immune genes implicated in multiple sclerosis pathology are shown to be primed but not expressed in oligodendrocyte precursor cells in both mouse and human.