Epigenetics in immune cells

Epigenetics in immune cells is the study of changes in gene activity that persist following immune cell division and do not involve alteration of the nucleotide sequence. Epigenetic mechanisms include DNA methylation and chromatic remodelling and they provide a molecular basis for cellular memory.

Latest Research and Reviews

  • Research | | open

    Antibodies are generated through remote genomic interactions involving immunoglobulin variable (VH), diversity (DH) and joining (JH) gene segments. Here the authors develop a strategy to track VH-DHJH motion in B-lymphocytes and provide evidence that chromosome organisation near the sol-gel phase transition dictates the timing of genomic interactions to orchestrate gene expression and somatic recombination.

    • Nimish Khanna
    • , Yaojun Zhang
    • , Joseph S. Lucas
    • , Olga K. Dudko
    •  & Cornelis Murre
  • Reviews |

    In this Review, Natoli and Ostuni discuss the mechanisms of adaptation and memory in immunity, with the aim of providing basic concepts that rationalize the properties and molecular bases of these essential processes.

    • Gioacchino Natoli
    •  & Renato Ostuni
    Nature Immunology 20, 783-792
  • Research |

    • Omar Khan
    • , Josephine R. Giles
    • , Sierra McDonald
    • , Sasikanth Manne
    • , Shin Foong Ngiow
    • , Kunal P. Patel
    • , Michael T. Werner
    • , Alexander C. Huang
    • , Katherine A. Alexander
    • , Jennifer E. Wu
    • , John Attanasio
    • , Patrick Yan
    • , Sangeeth M. George
    • , Bertram Bengsch
    • , Ryan P. Staupe
    • , Greg Donahue
    • , Wei Xu
    • , Ravi K. Amaravadi
    • , Xiaowei Xu
    • , Giorgos C. Karakousis
    • , Tara C. Mitchell
    • , Lynn M. Schuchter
    • , Jonathan Kaye
    • , Shelley L. Berger
    •  & E. John Wherry
    Nature, 1-13
  • Research | | open

    Autoreactive T cells are deleted in the thymus via thymic negative selection and Bim-mediated apoptosis. Here the authors identify a cis-acting enhancer, EBAB, that is essential for proper Bim expression and apoptosis induction, and show that EBAB deficiency specifically impairs thymic negative selection without affecting peripheral T cell homeostasis.

    • Miki Arai Hojo
    • , Kyoko Masuda
    • , Hiroaki Hojo
    • , Yosuke Nagahata
    • , Keiko Yasuda
    • , Daiya Ohara
    • , Yusuke Takeuchi
    • , Keiji Hirota
    • , Yutaka Suzuki
    • , Hiroshi Kawamoto
    •  & Shinpei Kawaoka
  • Research | | open

    The inability of T cells to properly mount anti-tumour immunity underlies failed cancer immune surveillance or therapy. Here the authors show that a microRNA, miR-155, suppresses Ship1 phosphatase expression to modulate epigenetic reprogramming of CD8 T cell differentiation via the Phf19/PRC2 axis, thereby implicating a novel aspect of cancer immunity regulation.

    • Yun Ji
    • , Jessica Fioravanti
    • , Wei Zhu
    • , Hongjun Wang
    • , Tuoqi Wu
    • , Jinhui Hu
    • , Neal E. Lacey
    • , Sanjivan Gautam
    • , John B. Le Gall
    • , Xia Yang
    • , James D. Hocker
    • , Thelma M. Escobar
    • , Shan He
    • , Stefania Dell’Orso
    • , Nga V. Hawk
    • , Veena Kapoor
    • , William G. Telford
    • , Luciano Di Croce
    • , Stefan A. Muljo
    • , Yi Zhang
    • , Vittorio Sartorelli
    •  & Luca Gattinoni

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