Eosinophils are important mediators of allergic responses, but how they are recruited to the inflamed site is still unclear. Here the authors show that CD103⁺ cDC1 cells secrete CCL17 and CCL22 for eosinophil recruitment, with this process promoted by CD24⁻CD11b⁺ DC2s in the early phase but suppressed by CD24⁺ cDC2s in the late phase.

Lian Willetts et al. demonstrate that vesicle-associated membrane protein 7 (VAMP 7), a principal component of the membrane fusion machinery, promotes eosinophil degranulation in allergic airway inflammation. This study suggests VAMP7 as a therapeutic target for ameliorating asthma.

Tissue-resident eosinophils selectively secrete cytokines and other mediators that have diverse functions in health and disease.