Enzyme mechanisms articles within Scientific Reports

Featured

• Article
  30 March 2024 | Open Access

  Network analysis of the proteome and peptidome sheds light on human milk as a biological system

  • Pieter M. Dekker
  • , Sjef Boeren
  •  & Kasper A. Hettinga

• Article
  01 February 2024 | Open Access

  The impact of selected xanthophylls on oil hydrolysis by pancreatic lipase: in silico and in vitro studies

  • Grzegorz Dąbrowski
  • , Sylwester Czaplicki
  •  & Iwona Konopka

• Article
  20 December 2023 | Open Access

  Exploring the hemicellulolytic properties and safety of Bacillus paralicheniformis as stepping stone in the use of new fibrolytic beneficial microbes

  • Serigne Inssa Ngom
  • , Soufiane Maski
  •  & Christel Béra-Maillet

• Article
  15 December 2023 | Open Access

  Structural insights into N-terminal methionine cleavage by the human mitochondrial methionine aminopeptidase, MetAP1D

  • Yeon Lee
  • , Hayoung Kim
  •  & Hyoun Sook Kim

• Article
  12 December 2023 | Open Access

  Enzyme mechanistic studies of NMA1982, a protein tyrosine phosphatase and potential virulence factor in Neisseria meningitidis

  • Shuangding Wu
  • , Mathieu Coureuil
  •  & Lutz Tautz

• Article
  20 November 2023 | Open Access

  Inhibition of ALDH2 by quercetin glucuronide suggests a new hypothesis to explain red wine headaches

  • Apramita Devi
  • , Morris Levin
  •  & Andrew L. Waterhouse

• Article
  17 November 2023 | Open Access

  Identification and characterization of a novel heparinase PCHepII from marine bacterium Puteibacter caeruleilacunae

  • Danrong Lu
  • , Luping Wang
  •  & Qingdong Zhang

• Article
  30 September 2023 | Open Access

  Discovery of a cystathionine γ-lyase (CSE) selective inhibitor targeting active-site pyridoxal 5′-phosphate (PLP) via Schiff base formation

  • Honami Echizen
  • , Kenjiro Hanaoka
  •  & Yasuteru Urano

• Article
  31 August 2023 | Open Access

  Biochemical analysis of Komagataella phaffii oxidative folding proposes novel regulatory mechanisms of disulfide bond formation in yeast

  • Arianna Palma
  • , Lukas A. Rettenbacher
  •  & Lloyd Ruddock

• Article
  22 August 2023 | Open Access

  Modified polysulfone membrane facilitates rapid separation of plasma from whole blood for an effective anti-SARS-CoV-2-IgM diagnosis

  • Maryam Ijadi Bajestani
  •  & Hossein Ahmadzadeh

• Article
  26 June 2023 | Open Access

  Amino acid positions near the active site determine the reduced activity of human ACOD1 compared to murine ACOD1

  • Fangfang Chen
  • , Israfil Yalcin
  •  & Konrad Büssow

• Article
  17 June 2023 | Open Access

  Cannabis sativa-based oils against aluminum-induced neurotoxicity

  • Carla Alves
  • , Wagner Antonio Tamagno
  •  & Leonardo José Gil Barcellos

• Article
  02 June 2023 | Open Access

  Human soluble CD39 displays substrate inhibition in a substrate-specific manner

  • Venkat M. K. Vadlamani
  • , Kavinda K. J. Gunasinghe
  •  & Matthew T. Harper

• Article
  11 May 2023 | Open Access

  H₂O₂ selectively damages the binuclear iron-sulfur cluster N1b of respiratory complex I

  • Lisa Strotmann
  • , Caroline Harter
  •  & Thorsten Friedrich

• Article
  04 May 2023 | Open Access

  Mechanism-based and computational modeling of hydrogen sulfide biogenesis inhibition: interfacial inhibition

  • Laurent Le Corre
  •  & Dominique Padovani

• Article
  01 April 2023 | Open Access

  The thiolation of uridine 34 in tRNA, which controls protein translation, depends on a [4Fe-4S] cluster in the archaeum Methanococcus maripaludis

  • Ornella Bimai
  • , Pierre Legrand
  •  & Béatrice Golinelli-Pimpaneau

• Article
  30 March 2023 | Open Access

  Utilizing genetic code expansion to modify N-TIMP2 specificity towards MMP-2, MMP-9, and MMP-14

  • Hezi Hayun
  • , Matt Coban
  •  & Niv Papo

• Article
  28 March 2023 | Open Access

  Coenzyme A binding sites induce proximal acylation across protein families

  • Chris Carrico
  • , Andrew Cruz
  •  & Eric Verdin

• Article
  12 January 2023 | Open Access

  In silico and in vitro studies confirm Ondansetron as a novel acetylcholinesterase and butyrylcholinesterase inhibitor

  • Asma Gholami
  • , Dariush Minai-Tehrani
  •  & Leif A. Eriksson

• Article
  10 January 2023 | Open Access

  Magnetic field and nuclear spin influence on the DNA synthesis rate

  • Sergey V. Stovbun
  • , Dmitry V. Zlenko
  •  & Anatoly L. Buchachenko

• Article
  07 December 2022 | Open Access

  Live imaging of apoptotic signaling flow using tunable combinatorial FRET-based bioprobes for cell population analysis of caspase cascades

  • Miho Suzuki
  • , Yutaka Shindo
  •  & Kotaro Oka

• Article
  05 December 2022 | Open Access

  Mechanistic investigation of SARS-CoV-2 main protease to accelerate design of covalent inhibitors

  • Hoshin Kim
  • , Darin Hauner
  •  & Neeraj Kumar

• Article
  22 November 2022 | Open Access

  In vitro biochemical assessment of mixture effects of two endocrine disruptors on INS-1 cells

  • Lamidi W. B. Olaniyan
  •  & Anthony I. Okoh

• Article
  20 October 2022 | Open Access

  A critical path to producing high quality, reproducible data from quantitative western blot experiments

  • Sean C. Taylor
  • , Luciana K. Rosselli-Murai
  •  & Isabelle Plante

• Article
  20 July 2022 | Open Access

  Vanillin reduction in the biosynthetic pathway of capsiate, a non-pungent component of Capsicum fruits, is catalyzed by cinnamyl alcohol dehydrogenase

  • Kaori Sano
  • , Yuya Uzawa
  •  & Kenji Kobata

• Article
  16 July 2022 | Open Access

  Electrostatic interactions between single arginine and phospholipids modulate physiological properties of sarcoplasmic reticulum Ca²⁺-ATPase

  • Kazuo Yamasaki
  • , Takashi Daiho
  •  & Hiroshi Suzuki

• Article
  05 July 2022 | Open Access

  Structure and function of cancer-related developmentally regulated GTP-binding protein 1 (DRG1) is conserved between sponges and humans

  • Silvestar Beljan
  • , Kristina Dominko
  •  & Helena Ćetković

• Article
  08 June 2022 | Open Access

  Substrate-dependent modulation of the leukotriene A₄ hydrolase aminopeptidase activity and effect in a murine model of acute lung inflammation

  • Kyung Hyeon Lee
  • , Nadia Fazal Ali
  •  & Mikell Paige

• Article
  04 May 2022 | Open Access

  First crystal structures of 1-deoxy-d-xylulose 5-phosphate synthase (DXPS) from Mycobacterium tuberculosis indicate a distinct mechanism of intermediate stabilization

  • Robin M. Gierse
  • , Rick Oerlemans
  •  & Matthew R. Groves

• Article
  28 April 2022 | Open Access

  Randomised trial of intravenous thiamine and/or magnesium sulphate administration on erythrocyte transketolase activity, lactate concentrations and alcohol withdrawal scores

  • Donogh Maguire
  • , Alana Burns
  •  & Donald C. McMillan

• Article
  17 March 2022 | Open Access

  Queueing theory model of pentose phosphate pathway

  • Sylwester M. Kloska
  • , Krzysztof Pałczyński
  •  & Tadeusz A. Wysocki

• Article
  09 March 2022 | Open Access

  Nematicidal activity of seaweed-synthesized silver nanoparticles and extracts against Meloidogyne incognita on tomato plants

  • Rehab Y. Ghareeb
  • , Nihal Galal El-Din Shams El-Din
  •  & Nader R. Abdelsalam

• Article
  07 February 2022 | Open Access

  The ACE genes in Aphelenchoides besseyi isolates and their expression correlation to the fenamiphos treatment

  • Jung-Kai Hsu
  • , Chia-Wei Weng
  •  & Peichen Janet Chen

• Article
  02 February 2022 | Open Access

  Comprehensive characterization and molecular insights into the salt tolerance of a Cu, Zn-superoxide dismutase from an Indian Mangrove, Avicennia marina

  • Rajat Kanti Sarkar
  • , Moumita Bhowmik
  •  & Kashinath Bhattacharya

• Article
  25 January 2022 | Open Access

  Pro108Ser mutation of SARS-CoV-2 3CL^pro reduces the enzyme activity and ameliorates the clinical severity of COVID-19

  • Kodai Abe
  • , Yasuaki Kabe
  •  & Kenjiro Kosaki

• Article
  13 January 2022 | Open Access

  Biochemical and structural characterization of quizalofop-resistant wheat acetyl-CoA carboxylase

  • Raven Bough
  •  & Franck E. Dayan

• Article
  27 December 2021 | Open Access

  Kinetic control of nascent protein biogenesis by peptide deformylase

  • Lena A. K. Bögeholz
  • , Evan Mercier
  •  & Marina V. Rodnina

• Article
  23 November 2021 | Open Access

  The encapsulin from Thermotoga maritima is a flavoprotein with a symmetry matched ferritin-like cargo protein

  • Benjamin J. LaFrance
  • , Caleb Cassidy-Amstutz
  •  & David F. Savage

• Article
  19 November 2021 | Open Access

  β-elimination of hyaluronate by red king crab hyaluronidase

  • Dmitrii Sliadovskii
  • , Tatyana Ponomareva
  •  & Evgeny Sogorin

• Article
  02 November 2021 | Open Access

  Assessment of four organophosphorus pesticides as inhibitors of human acetylcholinesterase and butyrylcholinesterase

  • Tena Čadež
  • , Dora Kolić
  •  & Zrinka Kovarik

• Article
  01 November 2021 | Open Access

  Identification of the first highly selective inhibitor of human lactate dehydrogenase B

  • Sachio Shibata
  • , Satoshi Sogabe
  •  & Tomoyoshi Soga

• Article
  29 September 2021 | Open Access

  Prevalence of elevated serum fatty acid synthase in chronic limb-threatening ischemia

  • Shirli Tay
  • , Gayan S. De Silva
  •  & Mohamed A. Zayed

• Article
  28 September 2021 | Open Access

  Redox status of cysteines does not alter functional properties of human dUTPase but the Y54C mutation involved in monogenic diabetes decreases protein stability

  • Judit Eszter Szabó
  • , Kinga Nyíri
  •  & Beáta Vértessy

• Article
  23 September 2021 | Open Access

  Revealing Escherichia coli type II l-asparaginase active site flexible loop in its open, ligand-free conformation

  • Maristella Maggi
  • , Massimiliano Meli
  •  & Claudia Scotti

• Article
  09 September 2021 | Open Access

  Multibiomarker responses to polycyclic aromatic hydrocarbons and microplastics in thumbprint emperor Lethrinus harak from a South Pacific locally managed marine area

  • Rufino Varea
  • , Andrew Paris
  •  & Susanna Piovano

• Article
  01 September 2021 | Open Access

  Revealing the molecular interplay of curcumin as Culex pipiens Acetylcholine esterase 1 (AChE1) inhibitor

  • Priyashi Rao
  • , Dweipayan Goswami
  •  & Rakesh M. Rawal

• Article
  13 August 2021 | Open Access

  The ERAP1 active site cannot productively access the N-terminus of antigenic peptide precursors stably bound onto MHC class I

  • George Mavridis
  • , Anastasia Mpakali
  •  & Efstratios Stratikos

• Article
  11 August 2021 | Open Access

  Structural basis of the complementary activity of two ketosynthases in aryl polyene biosynthesis

  • Woo Cheol Lee
  • , Sungjae Choi
  •  & Yangmee Kim

• Article
  26 July 2021 | Open Access

  Role of cholesterol in substrate recognition by \(\gamma\)-secretase

  • Łukasz Nierzwicki
  • , Michał Olewniczak
  •  & Jacek Czub

• Article
  01 July 2021 | Open Access

  A pan-cancer transcriptomic study showing tumor specific alterations in central metabolism

  • Ilir Sheraj
  • , N. Tulin Guray
  •  & Sreeparna Banerjee