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An increasing body of evidence supports a role for B cells in the pathogenesis of type 1 diabetes mellitus (T1DM). Here, the authors discuss the mechanisms and consequences of B cell activation in T1DM and how these cells might contribute to the development of diabetic kidney disease.
Romosozumab, a recently developed sclerostin inhibitor, stimulates bone formation and inhibits bone resorption, thereby markedly increasing bone mass and reducing fracture risk. But will a red flag regarding possible adverse cardiovascular events derail this promising new drug for osteoporosis?
The first large-scale, multicentric analysis of long-term results with Gamma Knife (Elekta) radiosurgery in the therapeutically challenging area of Cushing disease shows that, in selected patients, this radiation technique enables hormonal control to be achieved in most patients with relatively few adverse effects but with a significant risk of disease recurrence.