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| Open AccessModulating gene regulation function by chemically controlled transcription factor clustering
Transcription factor (TF) condensates appear to be pervasive, yet their roles remain debated. Here, the authors use a synthetic biology approach to show that TF clusters causally amplify transcription and can confer bimodality and “memory”.
- Jiegen Wu
- , Baoqiang Chen
- & Yihan Lin
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| Open AccessC. elegans colony formation as a condensation phenomenon
Phase separation phenomena have emerged as being of critical importance in biology. Here, using colony formation in C. elegans as model, the authors demonstrate that the basic concepts that underpin phase separation at a molecular level also apply to collective phenomena at the level of a population of organisms.
- Yuping Chen
- & James E. Ferrell Jr.
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Article
| Open AccessEmergence of collective oscillations in adaptive cells
There are many examples of cell populations exhibiting density-dependent collective oscillatory behaviour. Here, the authors show that sustained collective oscillations emerge when cells anticipate variation in signal and attempt to amplify it, a property that can be linked to adaptation.
- Shou-Wen Wang
- & Lei-Han Tang