Dynamic combinatorial chemistry

Definition

Dynamic combinatorial chemistry is an approach to molecular design in which building blocks combine through reversible chemical reactions to form libraries of complex structures. These dynamic combinatorial libraries are responsive to external influence (biomolecules, for example), which alter the relative thermodynamic stabilities of members of the library and can shift product distributions.

Latest Research and Reviews

News and Comment

  • News and Views |

    'Click' chemistry allows for the linking together of chemical modules, however, there are currently no methods that also allow for facile 'declicking' to unlink them. Now, a method has been developed to click together amines and thiols, and then allow a chemically triggered declick reaction to release the original molecular components.

    • David A. Fulton
    Nature Chemistry 8, 899–900
  • News and Views |

    The scope of dynamic combinatorial chemistry is somewhat limited by the small number of predictably reversible reactions. Now, secondary alcohols are shown to quickly and reversibly react with iminium ions to form hemiaminal ethers, opening up opportunites for their use in the construction of complex — and functional — dynamic architectures.

    • Ognjen Š. Miljanić
    Nature Chemistry 3, 909–910