Drug discovery

Definition

Drug discovery is the process through which potential new medicines are identified. It involves a wide range of scientific disciplines, including biology, chemistry and pharmacology.

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Latest Research and Reviews

  • Protocols |

    The levels of monoamines and their cofactors in cerebrospinal fluid are strong indicators for dopamine and serotonin biosynthesis and turnover. This protocol describes a set of HPLC-based approaches for the quantitative detection of these molecules.

    • Marta Batllori
    • , Marta Molero-Luis
    • , Aida Ormazabal
    • , Mercedes Casado
    • , Cristina Sierra
    • , Angels García-Cazorla
    • , Manju Kurian
    • , Simon Pope
    • , Simon J Heales
    •  & Rafael Artuch
    Nature Protocols 12, 2359–2375
  • Research |

    The development of selective ubiquitin-specific protease-7 (USP7) inhibitors GNE-6640 and GNE-6776, which induce tumour cell death and reveal differential kinetics of Lys-48 and Lys-63-linked ubiquitin chain depolymerization by USP7.

    • Lorna Kategaya
    • , Paola Di Lello
    • , Lionel Rougé
    • , Richard Pastor
    • , Kevin R. Clark
    • , Jason Drummond
    • , Tracy Kleinheinz
    • , Eva Lin
    • , John-Paul Upton
    • , Sumit Prakash
    • , Johanna Heideker
    • , Mark McCleland
    • , Maria Stella Ritorto
    • , Dario R. Alessi
    • , Matthias Trost
    • , Travis W. Bainbridge
    • , Michael C. M. Kwok
    • , Taylur P. Ma
    • , Zachary Stiffler
    • , Bradley Brasher
    • , Yinyan Tang
    • , Priyadarshini Jaishankar
    • , Brian R. Hearn
    • , Adam R. Renslo
    • , Michelle R. Arkin
    • , Frederick Cohen
    • , Kebing Yu
    • , Frank Peale
    • , Florian Gnad
    • , Matthew T. Chang
    • , Christiaan Klijn
    • , Elizabeth Blackwood
    • , Scott E. Martin
    • , William F. Forrest
    • , James A. Ernst
    • , Chudi Ndubaku
    • , Xiaojing Wang
    • , Maureen H. Beresini
    • , Vickie Tsui
    • , Carsten Schwerdtfeger
    • , Robert A. Blake
    • , Jeremy Murray
    • , Till Maurer
    •  & Ingrid E. Wertz
  • Research |

    Small molecules are identified that inhibit the ubiquitin-specific protease USP7 with high affinity and specificity as explained by co-crystal structures, and are shown to reduce tumour growth in mice.

    • Andrew P. Turnbull
    • , Stephanos Ioannidis
    • , Wojciech W. Krajewski
    • , Adan Pinto-Fernandez
    • , Claire Heride
    • , Agnes C. L. Martin
    • , Louise M. Tonkin
    • , Elizabeth C. Townsend
    • , Shane M. Buker
    • , David R. Lancia
    • , Justin A. Caravella
    • , Angela V. Toms
    • , Thomas M. Charlton
    • , Johanna Lahdenranta
    • , Erik Wilker
    • , Bruce C. Follows
    • , Nicola J. Evans
    • , Lucy Stead
    • , Cristina Alli
    • , Vladislav V. Zarayskiy
    • , Adam C. Talbot
    • , Alexandre J. Buckmelter
    • , Minghua Wang
    • , Crystal L. McKinnon
    • , Fabienne Saab
    • , Joanna F. McGouran
    • , Hannah Century
    • , Malte Gersch
    • , Marc S. Pittman
    • , C. Gary Marshall
    • , Tony M. Raynham
    • , Mary Simcox
    • , Lorna M. D. Stewart
    • , Sheila B. McLoughlin
    • , Jaime A. Escobedo
    • , Kenneth W. Bair
    • , Christopher J. Dinsmore
    • , Tim R. Hammonds
    • , Sunkyu Kim
    • , Sylvie Urbé
    • , Michael J. Clague
    • , Benedikt M. Kessler
    •  & David Komander
  • Reviews |

    Structure-based computational methods have contributed to recent successes in the development of small molecules to study GPCR function and to act as therapeutics, including the identification of new ligands for orphan GPCRs, allosteric regulators, and biased ligands.

    • Bryan L Roth
    • , John J Irwin
    •  & Brian K Shoichet
    Nature Chemical Biology 13, 1143–1151

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