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| Open AccessPredicting FFAR4 agonists using structure-based machine learning approach based on molecular fingerprints
- Zaid Anis Sherwani
- , Syeda Sumayya Tariq
- & Zaheer Ul-Haq
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| Open AccessExploring a repurposed candidate with dual hIDO1/hTDO2 inhibitory potential for anticancer efficacy identified through pharmacophore-based virtual screening and in vitro evaluation
- Nourhan M. Aboomar
- , Omar Essam
- & Reem K. Arafa
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| Open AccessHBCVTr: an end-to-end transformer with a deep neural network hybrid model for anti-HBV and HCV activity predictor from SMILES
- Ittipat Meewan
- , Jiraporn Panmanee
- & Pichaya Lertvilai
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| Open AccessDiscovery of gefitinib-1,2,3-triazole derivatives against lung cancer via inducing apoptosis and inhibiting the colony formation
- En Gao
- , Ya Wang
- & Shouhu Li
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| Open AccessDesign of three-component essential oil extract mixture from Cymbopogon flexuosus, Carum carvi, and Acorus calamus with enhanced antioxidant activity
- Hamza Assaggaf
- , Mohamed Jeddi
- & Naoufal El Hachlafi
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Article
| Open AccessHexahydrocannabinol (HHC) and Δ9-tetrahydrocannabinol (Δ9-THC) driven activation of cannabinoid receptor 1 results in biased intracellular signaling
- Oleh Durydivka
- , Petr Palivec
- & Martin Kuchar
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Article
| Open AccessTumor growth-arrest effect of tetrahydroquinazoline-derivative human topoisomerase II-alpha inhibitor in HPV-negative head and neck squamous cell carcinoma
- Patrizia Sarogni
- , Nicoletta Brindani
- & Valerio Voliani
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| Open AccessEpigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia
- Zachary C. Rosenthal
- , Daniel M. Fass
- & Stephen J. Haggarty
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| Open AccessFactors associated with hematological adverse reactions of drugs authorized via the centralized procedure
- Ivana Stević
- , Slobodan M. Janković
- & Dragana Lakić
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Article
| Open AccessSMS121, a new inhibitor of CD36, impairs fatty acid uptake and viability of acute myeloid leukemia
- Hannah Åbacka
- , Samuele Masoni
- & Karin Lindkvist-Petersson
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Article
| Open AccessSynthesis, biofilm formation inhibitory, and inflammation inhibitory activities of new coumarin derivatives
- Ghada E. Ahmed
- , Zeinab A. Elshahid
- & Anhar Abdel-Aziem
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Article
| Open AccessProtein characteristics substantially influence the propensity of activity cliffs among kinase inhibitors
- Safa Daoud
- & Mutasem Taha
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Article
| Open AccessL-NAC and L-NAC methyl ester prevent and overcome physical dependence to fentanyl in male rats
- James N. Bates
- , Santhosh M. Baby
- & Stephen J. Lewis
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Article
| Open AccessNarazaciclib, a novel multi-kinase inhibitor with potent activity against CSF1R, FLT3 and CDK6, shows strong anti-AML activity in defined preclinical models
- Tao Yang
- , Hang Ke
- & Qi-Xiang Li
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Article
| Open AccessC16, a PKR inhibitor, suppresses cell proliferation by regulating the cell cycle via p21 in colorectal cancer
- Yu Hashimoto
- , Yoshio Tokumoto
- & Yoichi Hiasa
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Article
| Open AccessStatine-based peptidomimetic compounds as inhibitors for SARS-CoV-2 main protease (SARS-CoV‑2 Mpro)
- Pedro Henrique R. de A. Azevedo
- , Priscila G. Camargo
- & Estela Maris F. Muri
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| Open AccessAffinity chromatography reveals direct binding of the GATA4–NKX2-5 interaction inhibitor (3i-1000) with GATA4
- Mikael Jumppanen
- , Sini M. Kinnunen
- & Jari Yli-Kauhaluoma
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Article
| Open AccessDisruption of the pro-oncogenic c-RAF–PDE8A complex represents a differentiated approach to treating KRAS–c-RAF dependent PDAC
- Sean F. Cooke
- , Thomas A. Wright
- & Connor M. Blair
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Article
| Open AccessDissolution and antioxidant potential of apigenin self nanoemulsifying drug delivery system (SNEDDS) for oral delivery
- Boontida Morakul
- , Veerawat Teeranachaideekul
- & Varaporn Buraphacheep Junyaprasert
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Article
| Open AccessIn silico exploration of phenolics as modulators of penicillin binding protein (PBP) 2× of Streptococcus pneumoniae
- Jamiu Olaseni Aribisala
- , Nosipho Wendy S’thebe
- & Saheed Sabiu
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Article
| Open AccessSirolimus-coated Eustachian tube balloon dilatation for treating Eustachian tube dysfunction in a rat model
- Jeon Min Kang
- , Song Hee Kim
- & Jung-Hoon Park
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Article
| Open AccessMolecular modelling studies and in vitro enzymatic assays identified A 4-(nitrobenzyl)guanidine derivative as inhibitor of SARS-CoV-2 Mpro
- Kaio Maciel de Santiago-Silva
- , Priscila Goes Camargo
- & Marcelle de Lima Ferreira Bispo
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| Open AccessDevelopment of a high throughput system to screen compounds that revert the activated hepatic stellate cells to a quiescent-like state
- Yasuhiro Nakano
- , Eiko Saijou
- & Taketomo Kido
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Article
| Open AccessMolecular identification of Proteus mirabilis, Vibrio species leading to CRISPR-Cas9 modification of tcpA and UreC genes causing cholera and UTI
- Muhammad Naveed
- , Fatima Tahir
- & Abdullah F. Alasmari
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| Open AccessDesign, synthesis, biological assessment and molecular modeling studies of novel imidazothiazole-thiazolidinone hybrids as potential anticancer and anti-inflammatory agents
- Payal Kamboj
- , Anjali
- & Mohd. Amir
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Article
| Open AccessUsing Mendelian randomization provides genetic insights into potential targets for sepsis treatment
- Rui Xia
- , Meng Sun
- & Jianhua Li
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Article
| Open AccessAnticancer, antioxidant, and antibacterial activity of chemically fingerprinted extract from Cyclamen persicum Mill.
- Fuad Al-Rimawi
- , Mahmoud Khalid
- & Mohammed Bourhia
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Article
| Open AccessTranslational research of boron neutron capture therapy for spinal cord gliomas using rat model
- Ryo Kayama
- , Kohei Tsujino
- & Masahiko Wanibuchi
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Article
| Open AccessDP2 receptor activity sensor suited for antagonist screening and measurement of receptor dynamics in real-time
- Michael Kurz
- , Michaela Ulrich
- & Moritz Bünemann
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Article
| Open AccessDevelopment of chitosan lipid nanoparticles to alleviate the pharmacological activity of piperine in the management of cognitive deficit in diabetic rats
- Asmaa Badawy Darwish
- , Amira Mohamed Mohsen
- & Mostafa Mohamed Younis
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| Open AccessTDF and TAF inhibit liver cancer cell migration, invasion via p7TP3
- Jing Zhao
- , Li Zhou
- & Xiuling Li
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| Open AccessInferring molecular inhibition potency with AlphaFold predicted structures
- Pedro F. Oliveira
- , Rita C. Guedes
- & Andre O. Falcao
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| Open AccessHibiscus manihot L. flower extract induces anticancer activity through modulation of apoptosis and autophagy in A549 cells
- Minglu Xu
- , Mengxia Zhao
- & Guoying Yu
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| Open AccessInvestigation into safflower injection as a prophylactic treatment for retinal vein occlusion in a rabbit model
- Junling Li
- , Zhenfeng Guo
- & Jianguo Wu
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| Open AccessEZH2 as a major histone methyltransferase in PDGF-BB-activated orbital fibroblast in the pathogenesis of Graves’ ophthalmopathy
- Sopita Visamol
- , Tanapat Palaga
- & Sita Virakul
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| Open AccessNobiletin alleviates cisplatin-induced ototoxicity via activating autophagy and inhibiting NRF2/GPX4-mediated ferroptosis
- Wenao Song
- , Li Zhang
- & Zhiming Lu
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| Open AccessAI is a viable alternative to high throughput screening: a 318-target study
- Izhar Wallach
- , Denzil Bernard
- & Abraham Heifets
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Article
| Open AccessRosemary and neem: an insight into their combined anti-dandruff and anti-hair loss efficacy
- Mona M. Hashem
- , Dalia Attia
- & Maha M. Salama
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| Open AccessThe antihyperglycemic potential of pyrazolobenzothiazine 1, 1-dioxide novel derivative in mice using integrated molecular pharmacological approach
- Saman Taj
- , Usman Ali Ashfaq
- & Anwarul Hasan
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| Open AccessUTRN as a potential biomarker in breast cancer: a comprehensive bioinformatics and in vitro study
- Han Li
- , Wenjie Zhang
- & Yang Peng
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| Open AccessAnethole as a promising antidepressant for maternal separation stress in mice by modulating oxidative stress and nitrite imbalance
- Najmeh Rostami-Faradonbeh
- , Hossein Amini-Khoei
- & Zahra Lorigooini
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| Open AccessA combination of virtual screening, molecular dynamics simulation, MM/PBSA, ADMET, and DFT calculations to identify a potential DPP4 inhibitor
- Fateme Zare
- , Elaheh Ataollahi
- & Leila Emami
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| Open AccessB-Myb deficiency boosts bortezomib-induced immunogenic cell death in colorectal cancer
- Yuan-Jian Hui
- , Ting-Ting Yu
- & Wei-Xing Wang
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Article
| Open AccessSynthesis and biological evaluation of echinomycin analogues as potential colon cancer agent
- Keita Kojima
- , Hiroaki Konishi
- & Satoshi Ichikawa
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Article
| Open AccessTenovin 3 induces apoptosis and ferroptosis in EGFR 19del non small cell lung cancer cells
- Sha Lv
- , Qianrong Pan
- & Xueping Lei
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Article
| Open AccessComparison of efficacy and safety of equivalent doses of remimazolam versus propofol for gastroscopy anesthesia in elderly patients
- Di Chen
- , Min Liao
- & Hu Sun
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| Open AccessDesign, synthesis and bioactivity study on oxygen-heterocyclic-based pyran analogues as effective P-glycoprotein-mediated multidrug resistance in MCF-7/ADR cell
- Ashraf H. F. Abd El-Wahab
- , Rita M. A. Borik
- & Ahmed M. El-Agrody
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| Open AccessPodocalyxin promotes the formation of compact and chemoresistant cancer spheroids in high grade serous carcinoma
- Ngoc Le Tran
- , Yao Wang
- & Guiying Nie
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| Open AccessNetwork pharmacology, computational biology integrated surface plasmon resonance technology reveals the mechanism of ellagic acid against rotavirus
- Jiangang Zheng
- , Abdul Haseeb
- & Hejie Wang