Drosophila

Drosophila is a genus of two-winged flies commonly known as fruit flies that are used in evolutionary and developmental studies. D. melanogaster is an important model organism for the study of genetics and development.

Latest Research and Reviews

  • Research | | open

    Serine/threonine phosphatases such as PP1 associate with a large array of subunit proteins, such as ASPP (apoptosis-stimulating protein of p53) to achieve selective targeting. Here authors solved the crystal structure of the human ASPP2/PP1 complex and explain how ASPP2 can distinguish between PP1 isoforms.

    • M. Teresa Bertran
    • , Stéphane Mouilleron
    • , Yanxiang Zhou
    • , Rakhi Bajaj
    • , Federico Uliana
    • , Ganesan Senthil Kumar
    • , Audrey van Drogen
    • , Rebecca Lee
    • , Jennifer J. Banerjee
    • , Simon Hauri
    • , Nicola O’Reilly
    • , Matthias Gstaiger
    • , Rebecca Page
    • , Wolfgang Peti
    •  & Nicolas Tapon
  • Research | | open

    BMP ligands act as retrograde signalling molecules to regulate presynaptic development, and regulation of BMP receptors by endocytosis may be an important component of this signalling pathway. Here, the authors show that Abi-mediated macropinocytosis of BMP receptors in Drosophila larva and contributes to neuromuscular development.

    • Najin Kim
    • , Sungdae Kim
    • , Minyeop Nahm
    • , Danielle Kopke
    • , Joohyung Kim
    • , Eunsang Cho
    • , Min-Jung Lee
    • , Mihye Lee
    • , Seung Hyun Kim
    • , Kendal Broadie
    •  & Seungbok Lee
  • Research | | open

    Proteome and transcriptome often show poor correlation, hindering the system-wide analysis of post-transcriptional regulation. Here, the authors study proteome and transcriptome dynamics during Drosophila embryogenesis and present basic mathematical models describing the temporal regulation of most protein-RNA pairs.

    • Kolja Becker
    • , Alina Bluhm
    • , Nuria Casas-Vila
    • , Nadja Dinges
    • , Mario Dejung
    • , Sergi Sayols
    • , Clemens Kreutz
    • , Jean-Yves Roignant
    • , Falk Butter
    •  & Stefan Legewie
  • Research |

    VARNAM is a red-shifted genetically encoded voltage sensor based on the Ace opsin. It is applied in Drosophila, mouse brain slices and behaving mice. It can be readily combined with blue-light-sensitive tools for dual-color applications.

    • Madhuvanthi Kannan
    • , Ganesh Vasan
    • , Cheng Huang
    • , Simon Haziza
    • , Jin Zhong Li
    • , Hakan Inan
    • , Mark J. Schnitzer
    •  & Vincent A. Pieribone
    Nature Methods 15, 1108-1116
  • Research | | open

    Epithelial folding has mainly been linked to forces acting in the apical actomyosin network of cells. Here, the authors show using live imaging that two distinct mechanisms, changes in basal surface tension and changes in lateral surface tension, drive the formation of two folds in the Drosophila wing disc.

    • Liyuan Sui
    • , Silvanus Alt
    • , Martin Weigert
    • , Natalie Dye
    • , Suzanne Eaton
    • , Florian Jug
    • , Eugene W. Myers
    • , Frank Jülicher
    • , Guillaume Salbreux
    •  & Christian Dahmann
  • Research | | open

    • Athanassios D. Velentzas
    • , Panagiotis D. Velentzas
    • , Stamatia A. Katarachia
    • , Athanasios K. Anagnostopoulos
    • , Niki E. Sagioglou
    • , Eleni V. Thanou
    • , Maria M. Tsioka
    • , Vassiliki E. Mpakou
    • , Zoe Kollia
    • , Vassilios E. Gavriil
    • , Issidora S. Papassideri
    • , George Th. Tsangaris
    • , Alkiviadis-Constantinos Cefalas
    • , Evangelia Sarantopoulou
    •  & Dimitrios J. Stravopodis

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