DNA nanotechnology

DNA nanotechnology is a branch of nanotechnology concerned with the design, study and application of synthetic structures based on DNA. DNA nanotechnology takes advantage of the physical and chemical properties of DNA rather than the genetic information it carries.

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Latest Research and Reviews

  • Research |

    Nucleic acid nanotechnology offers a promising route towards the design and synthesis of reconfigurable biomolecular materials. Now, the combination of dynamic and structural DNA nanotechnology has enabled the dynamic control of the assembly and disassembly of DNA nanotubes. The process involves minimal synthetic gene systems, including an autonomous molecular oscillator.

    • Leopold N. Green
    • , Hari K. K. Subramanian
    • , Vahid Mardanlou
    • , Jongmin Kim
    • , Rizal F. Hariadi
    •  & Elisa Franco
  • Research | | open

    Intercalating molecules can significantly change the conformation of DNA. Here, the authors fabricated resonators fully composed of DNA forming bundles between microfabricated pillars to study the vibration property of the DNA bundles with/without intercalant molecules.

    • Stefano Stassi
    • , Monica Marini
    • , Marco Allione
    • , Sergei Lopatin
    • , Domenico Marson
    • , Erik Laurini
    • , Sabrina Pricl
    • , Candido Fabrizio Pirri
    • , Carlo Ricciardi
    •  & Enzo Di Fabrizio
  • Reviews |

    Nucleic acid scaffolds can be precisely interfaced with cellular components, making them interesting materials to probe and program immune cells. In this Perspective, the authors explore nucleic acid technologies for the quantitative detection of single immune cells and for modulating the immune response.

    • Maulik S. Jani
    • , Aneesh T. Veetil
    •  & Yamuna Krishnan
  • Research | | open

    Curli are bacterial functional amyloids that have gained interest as self-assembling biomaterial for biotechnology applications. Here, the authors show that DNA origami decorated with CsgB nucleator proteins induced the site-specific nucleation and subsequent fibrillization of CsgA proteins.

    • Xiuhai Mao
    • , Ke Li
    • , Mengmeng Liu
    • , Xinyu Wang
    • , Tianxin Zhao
    • , Bolin An
    • , Mengkui Cui
    • , Yingfeng Li
    • , Jiahua Pu
    • , Jiang Li
    • , Lihua Wang
    • , Timothy K. Lu
    • , Chunhai Fan
    •  & Chao Zhong
  • Research |

    A set of 355 self-assembling DNA ‘tiles’ can be reprogrammed to implement many different computer algorithms—including sorting, palindrome testing and divisibility by three—suggesting that molecular self-assembly could be a reliable algorithmic component in programmable chemical systems.

    • Damien Woods
    • , David Doty
    • , Cameron Myhrvold
    • , Joy Hui
    • , Felix Zhou
    • , Peng Yin
    •  & Erik Winfree
    Nature 567, 366-372

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