DNA nanomachines

Definition

DNA nanomachines are nanorobots made entirely or partially of DNA. DNA nanomachines can switch between defined molecular conformations and can be used as sensing, computing, actuating or therapeutic nanodevices.

Latest Research and Reviews

  • Research |

    Primer exchange reaction (PER) cascades have now been used to grow nascent single-stranded DNA with user-specified sequences following prescribed reaction pathways. PER synthesis occurs in a programmable, autonomous, in situ and environmentally responsive fashion, providing a platform for engineering molecular circuits and devices with a wide range of sensing, monitoring, recording, signal processing and actuation capabilities.

    • Jocelyn Y. Kishi
    • , Thomas E. Schaus
    • , Nikhil Gopalkrishnan
    • , Feng Xuan
    •  & Peng Yin
  • Research | | open

    The spatial organisation of nanostructures is fundamental to their function. Here, the authors develop a non-destructive, proximity-based method to record extensive spatial organization information in DNA molecules for later readout.

    • Thomas E. Schaus
    • , Sungwook Woo
    • , Feng Xuan
    • , Xi Chen
    •  & Peng Yin
  • Research | | open

    Responsive molecular machines can perform specific tasks triggered by environmental or chemical stimuli. Here, the authors show that antibodies can be used as inputs to modulate the binding of a molecular cargo to a designed DNA-based nanomachine, with potential applications in diagnostics and drug delivery.

    • Simona Ranallo
    • , Carl Prévost-Tremblay
    • , Andrea Idili
    • , Alexis Vallée-Bélisle
    •  & Francesco Ricci
  • Research |

    Although DNA nanotechnology has found many applications in developing functional structures, there has never been an independent device contained within a 3D crystal. Now, a self-assembled three-state device that can change the colour of its crystal by diffusion of DNA-ligated dyes has been reported, representing the potential to develop programmable nanomechanical devices.

    • Yudong Hao
    • , Martin Kristiansen
    • , Ruojie Sha
    • , Jens J. Birktoft
    • , Carina Hernandez
    • , Chengde Mao
    •  & Nadrian C. Seeman
    Nature Chemistry 9, 824–827
  • Research | | open

    Synthetic DNA nanomachines have been designed to perform a variety of tasks in vitro. Here, the authors build a nanomotor system that integrates a DNAzyme and DNA track on a gold nanoparticle, to facilitate cellular uptake, and apply it as a real-time miRNA imaging tool in living cells.

    • Hanyong Peng
    • , Xing-Fang Li
    • , Hongquan Zhang
    •  & X. Chris Le

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