Diabetes

Diabetes describes a group of metabolic diseases characterized by high blood sugar levels. Diabetes can be caused by the pancreas not producing insulin (type 1 diabetes) or by insulin resistance (cells do not respond to insulin; type 2 diabetes).

Latest Research and Reviews

  • Research |

    Pancreatic β-cells are highly connected, and this network is crucial for the pulsatile release of insulin. Here Salem and colleagues demonstrated the existence of leader β-cells that respond first to glucose and are more closely linked to the other β-cells. They also showed that glucose increases β-cell calcium dynamics and connectivity between the leader and non-leader β-cells.

    • Victoria Salem
    • , Luis Delgadillo Silva
    • , Kinga Suba
    • , Eleni Georgiadou
    • , S. Neda Mousavy Gharavy
    • , Nadeem Akhtar
    • , Aldara Martin-Alonso
    • , David C. A. Gaboriau
    • , Stephen M. Rothery
    • , Theodoros Stylianides
    • , Gaelle Carrat
    • , Timothy J. Pullen
    • , Sumeet Pal Singh
    • , David J. Hodson
    • , Isabelle Leclerc
    • , A. M. James Shapiro
    • , Piero Marchetti
    • , Linford J. B. Briant
    • , Walter Distaso
    • , Nikolay Ninov
    •  & Guy A. Rutter
    Nature Metabolism 1, 615-629
  • Research | | open

    Our understanding of the functional link between differential DNA methylation and type 2 diabetes and obesity remains limited. Here the authors present a blood-based EWAS of fasting glucose and insulin among 4808 non-diabetic Europeans and identify nine CpGs not previously implicated in glucose, insulin homeostasis and diabetes.

    • Jun Liu
    • , Elena Carnero-Montoro
    • , Jenny van Dongen
    • , Samantha Lent
    • , Ivana Nedeljkovic
    • , Symen Ligthart
    • , Pei-Chien Tsai
    • , Tiphaine C. Martin
    • , Pooja R. Mandaviya
    • , Rick Jansen
    • , Marjolein J. Peters
    • , Liesbeth Duijts
    • , Vincent W. V. Jaddoe
    • , Henning Tiemeier
    • , Janine F. Felix
    • , Gonneke Willemsen
    • , Eco J. C. de Geus
    • , Audrey Y. Chu
    • , Daniel Levy
    • , Shih-Jen Hwang
    • , Jan Bressler
    • , Rahul Gondalia
    • , Elias L. Salfati
    • , Christian Herder
    • , Bertha A. Hidalgo
    • , Toshiko Tanaka
    • , Ann Zenobia Moore
    • , Rozenn N. Lemaitre
    • , Min A Jhun
    • , Jennifer A. Smith
    • , Nona Sotoodehnia
    • , Stefania Bandinelli
    • , Luigi Ferrucci
    • , Donna K. Arnett
    • , Harald Grallert
    • , Themistocles L. Assimes
    • , Lifang Hou
    • , Andrea Baccarelli
    • , Eric A. Whitsel
    • , Ko Willems van Dijk
    • , Najaf Amin
    • , André G. Uitterlinden
    • , Eric J. G. Sijbrands
    • , Oscar H. Franco
    • , Abbas Dehghan
    • , Tim D. Spector
    • , Josée Dupuis
    • , Marie-France Hivert
    • , Jerome I. Rotter
    • , James B. Meigs
    • , James S. Pankow
    • , Joyce B. J. van Meurs
    • , Aaron Isaacs
    • , Dorret I. Boomsma
    • , Jordana T. Bell
    • , Ayşe Demirkan
    •  & Cornelia M. van Duijn
  • Reviews |

    Diabetic neuropathy is a complication of diabetes mellitus that results in loss of sensory function beginning in the extremities. This Primer summarizes the epidemiology, mechanisms, diagnosis and treatment of diabetic nephropathy and discusses the quality-of-life issues faced by patients.

    • Eva L. Feldman
    • , Brian C. Callaghan
    • , Rodica Pop-Busui
    • , Douglas W. Zochodne
    • , Douglas E. Wright
    • , David L. Bennett
    • , Vera Bril
    • , James W. Russell
    •  & Vijay Viswanathan

News and Comment