Diabetes insipidus articles from across Nature Portfolio

This PrimeView discusses the four types of diabetes insipidus (DI), central, nephrogenic and gestational DI), and primary polydipsia, and how the aetiology influences the management of the disorder.

Diabetes insipidus (DI) is a form of polyuria–polydipsia syndrome usually resulting from insufficient production or response to arginine vasopressin (in central, nephrogenic and gestational DI), except in primary polydipsia. This Primer discusses the types of DI and how aetiology influences management of the disorder.

Patients suffering from congenital nephrogenic diabetes insipidus (NDI) fail to concentrate urine due to mutations in vasopressin type 2 receptor (V2R). Here Ando et al. show that agents disrupting the interaction between PKA and AKAPs restore aquaporin-2 activity downstream of V2R, offering a therapeutic approach for the treatment of NDI.