Diabetes insipidus

Definition

Patients with diabetes insipidus have excessive thirst and excrete large amounts of extremely diluted urine. Diabetes insipidus is generally a result of either a lack of antidiuretic hormone or insensitivity to antidiuretic hormone causing kidney or nephron dysfunction.

Latest Research and Reviews

  • Research | | open

    Nrf2 regulates oxidative and electrophilic stress responses by modulating the expression of enzymes involved in detoxification pathways. Here Suzuki et al. show that Nrf2 activation in early tubular development promotes nephrogenic diabetes insipidus by regulating aquaporin 2 expression and trafficking and water permeability.

    • Takafumi Suzuki
    • , Shiori Seki
    • , Keiichiro Hiramoto
    • , Eriko Naganuma
    • , Eri H. Kobayashi
    • , Ayaka Yamaoka
    • , Liam Baird
    • , Nobuyuki Takahashi
    • , Hiroshi Sato
    •  & Masayuki Yamamoto
  • Research | | open

    The water channel AQP2 mediates the concentration of urine in the kidney. Here Ando et al. show that Wnt5 promotes collecting duct permeability by regulating AQP2 expression and localization through activation of the calmodulin/calcineurin signalling pathway.

    • Fumiaki Ando
    • , Eisei Sohara
    • , Tetsuji Morimoto
    • , Naofumi Yui
    • , Naohiro Nomura
    • , Eriko Kikuchi
    • , Daiei Takahashi
    • , Takayasu Mori
    • , Alain Vandewalle
    • , Tatemitsu Rai
    • , Sei Sasaki
    • , Yoshiaki Kondo
    •  & Shinichi Uchida
  • Reviews |

    Nephrogenic diabetes insipidus (NDI) is caused by inability of the kidneys to respond to arginine vasopressin and concentrate urine by reabsorption of water in the collecting duct. The disease can be congenital or acquired and has a substantial detrimental effect on the quality of life of affected patients. In this article, Bockenhauer and Bichet review the pathophysiology, diagnosis and current clinical management of NDI as well as potential future treatment strategies.

    • Detlef Bockenhauer
    •  & Daniel G. Bichet
  • Reviews |

    Lymphocytic hypophysitis—an inflammatory condition of presumed autoimmune etiology—is characterized by an enlargement of the pituitary gland, resulting in its dysfunction. Although found generally in peripartum women, this Case Study of a 29-year-old man, who was referred to a neurosurgical clinic for evaluation of a suprasellar mass and diabetes insipidus, illustrates the need to consider this disorder in men.

    • Ole-Petter R. Hamnvik
    • , Anna R. Laury
    • , Edward R. Laws Jr
    •  & Ursula B. Kaiser