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Developmental neurogenesis is the formation of functional, mature neurons from neural stem cells during development of an organism. Understanding developmental neurogenesis helps in the understanding of congenital neurological disorders.
Saade et al. show that Shh activation promotes symmetric pericentrin-mediated docking of PKA to centrosomes and the expansion of the motor neuron progenitor pool through symmetric proliferative divisions.
In the spinal cord, some Hox genes are transcribed in progenitors while their proteins are only detected in differentiating postmitotic motor neurons. Here, the authors show that miRNAs (specifically mir-27) regulate post-transcriptional Hoxa5 expression in motor neurons.