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| Open AccessA self-stabilized and water-responsive deliverable coenzyme-based polymer binary elastomer adhesive patch for treating oral ulcer
The therapeutic benefits of biomaterials-based treatments for oral ulcer have been limited by the materials’ poor adhesion and short-time retention in oral cavity. Here, the authors report a polymer binary elastomer adhesive patch that allows water-responsive sustainable delivery of bioactive small molecules and durable adhesion to oral mucosal wounds to achieve efficient therapy of oral ulcer.
- Chunyan Cui
- , Li Mei
- & Wenguang Liu
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Article
| Open AccessNeural crest E-cadherin loss drives cleft lip/palate by epigenetic modulation via pro-inflammatory gene–environment interaction
Cleft lip and palate is a common birth defect thought to involve both genetic and environmental components in its etiology. Here they identify a mechanism involving inflammation and E-cadherin mutations that reduces neural crest migration, leading to craniofacial defects.
- Lucas Alvizi
- , Diogo Nani
- & Roberto Mayor
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Article
| Open AccessNanoparticulate cell-free DNA scavenger for treating inflammatory bone loss in periodontitis
Periodontitis is a common type of inflammatory bone loss, and cell-free DNA (cfDNA) can be a major source that enhances the periodontal tissue destruction. Here, the authors show that a cfDNA-scavenging approach is able to ameliorate periodontitis by using nanoparticulate cfDNA scavenger.
- Hanyao Huang
- , Weiyi Pan
- & Kam W. Leong
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Article
| Open AccessPyro-catalysis for tooth whitening via oral temperature fluctuation
Tooth whitening becoming a common cosmetic treatment has led to the development of catalytic whitening solutions. Here, the authors report upon a thermally triggered, pyrocatalytic, catalyst which can use temperature changes from normal oral activity to breakdown stains and whiten teeth.
- Yang Wang
- , Shuhao Wang
- & Xuliang Deng
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Article
| Open AccessA fully automatic AI system for tooth and alveolar bone segmentation from cone-beam CT images
Accurate delineation of individual teeth and alveolar bones from dental cone-beam CT images is an essential step in digital dentistry for precision dental healthcare. Here, the authors present a deep learning system for efficient, precise, and fully automatic segmentation of real-patient CBCT images presenting highly variable appearances.
- Zhiming Cui
- , Yu Fang
- & Dinggang Shen
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Article
| Open AccessPiezo-catalysis for nondestructive tooth whitening
Tooth whitening has attracted significant interest; however, most techniques are potentially destructive. Here, the authors model the replacement of standard abrasives in toothpaste with piezoelectric particles for catalytic degradation of organic stains and report less damage than hydrogen peroxide treatment.
- Yang Wang
- , Xinrong Wen
- & Yaojin Wang
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Article
| Open AccessComputer simulations of food oral processing to engineer teeth cleaning
Oral care based foods are of great interest for increasing the dental health of animals. Here, the authors report on computer simulations to optimise the texture and geometry of food in order to maximise tooth abrasion and enhance cleaning efficiency.
- C. G. Skamniotis
- , M. Elliott
- & M. N. Charalambides
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Article
| Open AccessParathyroid hormone receptor signalling in osterix-expressing mesenchymal progenitors is essential for tooth root formation
How the parathyroid hormone-related protein receptor (PPR) and its ligand act in root formation and tooth eruption is unclear. Here, the authors identify osterix-expressing dental mesenchymal cells as progenitors for root formation and that PPR signalling mediates their differentiation and tooth eruption.
- Wanida Ono
- , Naoko Sakagami
- & Henry M. Kronenberg
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