Dengue virus

Dengue virus is an infectious agent that causes the tropical disease dengue fever in humans. This virus species is transmitted by mosquitoes (arthropods) and thus is an arbovirus.

Latest Research and Reviews

  • Reviews |

    The existence of four different serotypes of dengue virus poses a challenge to vaccine development, as pre-existing immunity can lead to severe disease during infection with a heterologous serotype. This Review analyses the mechanisms of protective and pathological adaptive immune responses in primary and secondary dengue infection.

    • Ashley L. St. John
    •  & Abhay P. S. Rathore
  • Research | | open

    The circadian clock can affect pathogen replication, but underlying molecular mechanisms are unclear. Here the authors demonstrate that the circadian components BMAL1 and REV-ERBα affect entry of hepatitis C virus (HCV) into hepatocytes and genome replication of HCV and related flaviviruses dengue and zika.

    • Xiaodong Zhuang
    • , Andrea Magri
    • , Michelle Hill
    • , Alvina G. Lai
    • , Abhinav Kumar
    • , Srinivasa Bhargav Rambhatla
    • , Claire L. Donald
    • , Andrea F. Lopez-Clavijo
    • , Simon Rudge
    • , Katherine Pinnick
    • , Wai Hoong Chang
    • , Peter A. C. Wing
    • , Ryan Brown
    • , Ximing Qin
    • , Peter Simmonds
    • , Thomas F. Baumert
    • , David Ray
    • , Andrew Loudon
    • , Peter Balfe
    • , Michael Wakelam
    • , Sam Butterworth
    • , Alain Kohl
    • , Catherine L. Jopling
    • , Nicole Zitzmann
    •  & Jane A. McKeating
  • Research |

    Although essential to restrict systemic replication, the small interfering RNA pathway fails to efficiently silence dengue virus in the midgut of Aedes aegypti in the absence of ectopic expression of the double-stranded RNA-binding protein Loqs2.

    • Roenick P. Olmo
    • , Alvaro G. A. Ferreira
    • , Tatiane C. Izidoro-Toledo
    • , Eric R. G. R. Aguiar
    • , Isaque J. S. de Faria
    • , Kátia P. R. de Souza
    • , Kátia P. Osório
    • , Lauriane Kuhn
    • , Philippe Hammann
    • , Elisa G. de Andrade
    • , Yaovi Mathias Todjro
    • , Marcele N. Rocha
    • , Thiago H. J. F. Leite
    • , Siad C. G. Amadou
    • , Juliana N. Armache
    • , Simona Paro
    • , Caroline D. de Oliveira
    • , Fabiano D. Carvalho
    • , Luciano A. Moreira
    • , Eric Marois
    • , Jean-Luc Imler
    •  & João T. Marques
    Nature Microbiology 3, 1385-1393
  • Research | | open

    Clinical trials for the CYD-TDV dengue vaccine showed that vaccine efficacy varies with prior dengue exposure, but baseline serostatus is only known for 12% of subjects. Here, Dorigatti et al. use machine learning to impute baseline serostatus and determine vaccine efficacy by baseline serostatus, age and dengue serotype.

    • I. Dorigatti
    • , C. A. Donnelly
    • , D. J. Laydon
    • , R. Small
    • , N. Jackson
    • , L. Coudeville
    •  & N. M. Ferguson

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