Cytoskeleton

Definition

The cytoskeleton is a network of filamentous and tubular protein structures that support cell shape, intracellular compartmentalisation and trafficking, cell migration and cell division. The key constituents of the cytoskeleton are actin filaments, microtubules and intermediate filaments.

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Latest Research and Reviews

  • Research | | open

    The molecular trigger that establishes cell polarity in the mammalian embryo is unclear. Here, the authors show that de novo polarisation of the mouse embryo at the 8-cell stage is directed by Phospholipase C and Protein kinase C and occurs in two phases: polarisation of actomyosin followed by the Par complex.

    • Meng Zhu
    • , Chuen Yan Leung
    • , Marta N. Shahbazi
    •  & Magdalena Zernicka-Goetz
  • Research | | open

    Adenomatous polyposis coli (APC) regulates the localization of some mRNAs at cellular protrusions but the underlying mechanisms and functional roles are not known. Here the authors show that APC-dependent RNAs are enriched in contractile protrusions, via detyrosinated microtubules, and enhance cell migration.

    • Tianhong Wang
    • , Susan Hamilla
    • , Maggie Cam
    • , Helim Aranda-Espinoza
    •  & Stavroula Mili
  • Research |

    Combined structural and microscopy approaches provide a model for how CAMSAP proteins recognize microtubule minus ends through their conserved CCK domains and protect microtubules from depolymerizing kinesin-13.

    • Joseph Atherton
    • , Kai Jiang
    • , Marcel M Stangier
    • , Yanzhang Luo
    • , Shasha Hua
    • , Klaartje Houben
    • , Jolien J E van Hooff
    • , Agnel-Praveen Joseph
    • , Guido Scarabelli
    • , Barry J Grant
    • , Anthony J Roberts
    • , Maya Topf
    • , Michel O Steinmetz
    • , Marc Baldus
    • , Carolyn A Moores
    •  & Anna Akhmanova
  • Reviews |

    The transcription factors YAP and TAZ have recently emerged as being conserved transducers of mechanical signals into cells and mediators of processes such as proliferation, migration and cell fate decision. The roles of YAP-mediated and TAZ-mediated mechanotransduction have now been documented in many physiological and pathological contexts, providing novel insights into cellular mechano-responses and their consequences.

    • Tito Panciera
    • , Luca Azzolin
    • , Michelangelo Cordenonsi
    •  & Stefano Piccolo
  • Research | | open

    The fission yeast cytokinetic ring assembles by Search-Capture-Pull-Release from precursor nodes that include formin Cdc12 and myosin Myo2. The authors reconstitute Search-Capture-Pull in vitro and find that Myo2 pulling on Cdc12-associated actin filaments mechano-inhibits Cdc12-mediated assembly, which enables proper ring assembly in vivo.

    • Dennis Zimmermann
    • , Kaitlin E. Homa
    • , Glen M. Hocky
    • , Luther W. Pollard
    • , Enrique M. De La Cruz
    • , Gregory A. Voth
    • , Kathleen M. Trybus
    •  & David R. Kovar
  • Research |

    A genetically encoded tension sensor module for measuring molecular forces at 3–5 pN along with tools for multiplexed tension sensing and data analysis reveal an intramolecular tension gradient across talin-1 during cell adhesion.

    • Pia Ringer
    • , Andreas Weißl
    • , Anna-Lena Cost
    • , Andrea Freikamp
    • , Benedikt Sabass
    • , Alexander Mehlich
    • , Marc Tramier
    • , Matthias Rief
    •  & Carsten Grashoff

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