Cytological techniques

Definition

Cytological techniques are methods used in the study or manipulation of cells. These include methods used in cell biology to culture, track, phenotype, sort and screen cells in populations or tissues, and molecular methods to understand cellular function.

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  • News and Views |

    High-throughput screening of large libraries of cyclic peptides expressed in bacteria yields rescuers of the pathogenic misfolding of proteins associated with neurodegenerative diseases.

    • Tobias Langenberg
    • , Joost Schymkowitz
    •  & Frederic Rousseau
  • News and Views |

    A global analysis of translation efficiency and RNA accumulation revealed that microRNAs in the unicellular green alga Chlamydomonas regulate target gene expression via RNA destabilization and translational repression like land plants and metazoans, yet in a different way.

    • Hiro-oki Iwakawa
    •  & Yukihide Tomari
    Nature Plants 3, 769–770
  • News and Views |

    A new study uses a Hi-C technique to demonstrate that condensin has a major role in remodeling interphase chromatin into mitotic chromosomes. This study provides insight into the mechanism whereby a centimeters-long DNA molecule is folded into a micrometers-long rod-shaped chromosome.

    • Tatsuya Hirano
    Nature Genetics 49, 1419–1420
  • Research Highlights |

    Using DNA barcoding, Lan et al. investigated the clonal evolution and dynamics of glioblastoma cells, and propose a model whereby proliferative heterogeneity is derived from stochastic fate decisions made by a homogeneous population of glioblastoma stem cells and their progeny.

    • Conor A. Bradley
    Nature Reviews Cancer 17, 574–575