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A cyst is a closed cluster of cells forming a sac that is surrounded by a membrane. The cells in this membrane are different in appearance and behaviour from the surrounding cells in that location. Cysts contain air, fluids, or semi-solid material and they can be formed from normal, abnormal, non-neoplastic or neoplastic tissues.
Dysregulation of an mTORC1 substrate-specific mechanism leads to constitutive activation of TFEB, and promotes kidney cystogenesis and tumorigenesis in a mouse model of Birt–Hogg–Dubé syndrome.
