Cyclic nucleotide-gated cation channels

Cyclic nucleotide-gated cation channels are cation channels controlled from inside the cell by second messengers cAMP and cGMP. They allow for transit of cations sodium, calcium and potassium across cellular membranes. These channels are involved in sensory signalling such as olfaction and vision as well as in cellular development, hormone release and chemotaxis.

Latest Research and Reviews

  • Research | | open

    Cyclic nucleotide gated channels are activated after binding cyclic nucleotides. Here, using single molecule force spectroscopy, the authors reveal that cyclic nucleotide binding causes conformational changes and tighter coupling of the S4 helix to the pore forming domain.

    • Sourav Maity
    • , Monica Mazzolini
    • , Manuel Arcangeletti
    • , Alejandro Valbuena
    • , Paolo Fabris
    • , Marco Lazzarino
    •  & Vincent Torre
  • Research | | open

    Cyclic nucleotide-gated channels mediate olfactory and visual responses. Using a fluorescent cGMP derivative, Nache et al. show that the rate of cyclic nucleotide release from CNGA2 depends on the extent to which this tetrameric receptor is liganded, revealing hysteresis in the gating mechanism.

    • Vasilica Nache
    • , Thomas Eick
    • , Eckhard Schulz
    • , Ralf Schmauder
    •  & Klaus Benndorf
  • Research |

    Cyclic nucleotide-gated channels are apparently voltage insensitive despite having the S4-type voltage sensor. Marchesi et al. show that the gating of wild-type CNGA1 and native CNG channels is voltage-independent in the presence of Li+, Na+ and K+, but that it is voltage-dependent in the presence of Rb+, Cs+ and organic cations.

    • Arin Marchesi
    • , Monica Mazzolini
    •  & Vincent Torre
  • Reviews |

    Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are known for their role in controlling the rhythmic activity of cardiac pacemaker cells and spontaneously firing neurons. They are now emerging as interesting targets not only for the development of drugs to lower heart rate but also for the treatment of diseases related to impaired neuronal activity, such as epilepsy and neuropathic pain.

    • Otilia Postea
    •  & Martin Biel
  • Research |

    At light levels where both rods and cones are active, their signals converge into shared downstream retinal circuitry. Using HCN1 deficient mice, this study shows that the signals from cone photoreceptors are overwhelmed when rod output is not regulated, suggesting a mechanism for how these systems interact.

    • Mathias W. Seeliger
    • , Arne Brombas
    • , Reto Weiler
    • , Peter Humphries
    • , Gabriel Knop
    • , Naoyuki Tanimoto
    •  & Frank Müller