Crohn's disease

Crohn’s disease is a chronic inflammatory disease of the gastrointestinal tract, mostly affecting the ileum. The inflammation can extend through the intestinal wall and tends to be asymmetric and in patches, with granulomas forming in some patients. Genetic, environmental, immunological and bacterial factors are all thought to contribute to the disease.

Latest Research and Reviews

  • Research | | open

    Distinguishing clinical subtypes of IBD is critical for optimal treatments, outcome prediction, and better understanding of disease pathogenesis. Here the authors phenotype blood and intestinal immune cells by mass cytometry and identify signatures associated with distinct disease states.

    • Samuel J. S. Rubin
    • , Lawrence Bai
    • , Yeneneh Haileselassie
    • , Gotzone Garay
    • , Chohee Yun
    • , Laren Becker
    • , Sarah E. Streett
    • , Sidhartha R. Sinha
    •  & Aida Habtezion
  • Research | | open

    The Inflammatory Bowel Disease Multi’omics Database includes longitudinal data encompassing a multitude of analyses of stool, blood and biopsies of more than 100 individuals, and provides a comprehensive description of host and microbial activities in inflammatory bowel diseases.

    • Jason Lloyd-Price
    • , Cesar Arze
    • , Ashwin N. Ananthakrishnan
    • , Melanie Schirmer
    • , Julian Avila-Pacheco
    • , Tiffany W. Poon
    • , Elizabeth Andrews
    • , Nadim J. Ajami
    • , Kevin S. Bonham
    • , Colin J. Brislawn
    • , David Casero
    • , Holly Courtney
    • , Antonio Gonzalez
    • , Thomas G. Graeber
    • , A. Brantley Hall
    • , Kathleen Lake
    • , Carol J. Landers
    • , Himel Mallick
    • , Damian R. Plichta
    • , Mahadev Prasad
    • , Gholamali Rahnavard
    • , Jenny Sauk
    • , Dmitry Shungin
    • , Yoshiki Vázquez-Baeza
    • , Richard A. White III
    • , Jason Bishai
    • , Kevin Bullock
    • , Amy Deik
    • , Courtney Dennis
    • , Jess L. Kaplan
    • , Hamed Khalili
    • , Lauren J. McIver
    • , Christopher J. Moran
    • , Long Nguyen
    • , Kerry A. Pierce
    • , Randall Schwager
    • , Alexandra Sirota-Madi
    • , Betsy W. Stevens
    • , William Tan
    • , Johanna J. ten Hoeve
    • , George Weingart
    • , Robin G. Wilson
    • , Vijay Yajnik
    • , Jonathan Braun
    • , Lee A. Denson
    • , Janet K. Jansson
    • , Rob Knight
    • , Subra Kugathasan
    • , Dermot P. B. McGovern
    • , Joseph F. Petrosino
    • , Thaddeus S. Stappenbeck
    • , Harland S. Winter
    • , Clary B. Clish
    • , Eric A. Franzosa
    • , Hera Vlamakis
    • , Ramnik J. Xavier
    •  & Curtis Huttenhower
    Nature 569, 655-662
  • Research | | open

    • Jerzy Ostrowski
    • , Krzysztof Goryca
    • , Izabella Lazowska
    • , Agnieszka Rogowska
    • , Agnieszka Paziewska
    • , Michalina Dabrowska
    • , Filip Ambrozkiewicz
    • , Jakub Karczmarski
    • , Aneta Balabas
    • , Anna Kluska
    • , Magdalena Piatkowska
    • , Natalia Zeber-Lubecka
    • , Maria Kulecka
    • , Andrzej Habior
    • , Michal Mikula
    • , Bozena Walewska-Zielecka
    • , Marek Krawczyk
    • , Halina Cichoz-Lach
    • , Piotr Milkiewicz
    • , Agnieszka Kowalik
    • , Krzysztof Mucha
    • , Joanna Raczynska
    • , Joanna Musialik
    • , Grzegorz Boryczka
    • , Michal Wasilewicz
    • , Irena Ciecko-Michalska
    • , Malgorzata Ferenc
    • , Maria Janiak
    • , Alina Kanikowska
    • , Rafal Stankiewicz
    • , Marek Hartleb
    • , Tomasz Mach
    • , Marian Grzymislawski
    • , Joanna Raszeja-Wyszomirska
    • , Ewa Wunsch
    • , Tomasz Bobinski
    • , Jaroslaw Kierkus
    • , Piotr Socha
    • , Michal Lodyga
    • , Maria Klopocka
    • , Barbara Iwanczak
    • , Katarzyna Bak-Drabik
    • , Jaroslaw Walkowiak
    • , Piotr Radwan
    • , Urszula Grzybowska-Chlebowczyk
    • , Bartosz Korczowski
    •  & Teresa Starzynska

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